Nano-sized graphene oxide coated nanopillars on microgroove polymer arrays that enhance skeletal muscle cell differentiation

The degeneration or loss of skeletal muscles, which can be caused by traumatic injury or disease, impacts most aspects of human activity. Among various techniques reported to regenerate skeletal muscle tissue, controlling the external cellular environment has been proven effective in guiding muscle...

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Bibliographic Details
Published in:Nano convergence 2021, 8(40), , pp.1-11
Main Authors: Choi, Hye Kyu, Kim, Cheol-Hwi, Lee, Sang Nam, Kim, Tae-Hyung, Oh, Byung-Keun
Format: Article
Language:English
Subjects:
Arrays
Cell adhesion
Cell behavior
Chemistry and Materials Science
Degeneration
Differentiation (biology)
Graphene
Materials Science
Micro−nano hybrid pattern
Muscles
Musculoskeletal system
Myogenesis
Myosin
Nano-sized graphene oxide
Nanomaterials
Nanoscale Science and Technology
Nanotechnology
Nanotechnology and Microengineering
Polydimethylsiloxane
Polymers
Substrates
고분자공학
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Summary:The degeneration or loss of skeletal muscles, which can be caused by traumatic injury or disease, impacts most aspects of human activity. Among various techniques reported to regenerate skeletal muscle tissue, controlling the external cellular environment has been proven effective in guiding muscle differentiation. In this study, we report a nano-sized graphene oxide (sGO)-modified nanopillars on microgroove hybrid polymer array (NMPA) that effectively controls skeletal muscle cell differentiation. sGO-coated NMPA (sG-NMPA) were first fabricated by sequential laser interference lithography and microcontact printing methods. To compensate for the low adhesion property of polydimethylsiloxane (PDMS) used in this study, graphene oxide (GO), a proven cytophilic nanomaterial, was further modified. Among various sizes of GO, sGO (
ISSN:2196-5404
2196-5404
DOI:10.1186/s40580-021-00291-6