Causal Association Between Alcohol Consumption and Atrial Fibrillation: A Mendelian Randomization Study

Previous observational studies presented a positive association between alcohol and atrial fibrillation (AF). However, previous studies using genetic polymorphisms on the causal relationship between alcohol consumption and AF have reported conflicting results. This study aimed to evaluate the causal...

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Published in:Korean circulation journal 2022, 52(3), , pp.220-230
Main Authors: Yang, Jung-Ho, Jeong, Ji-An, Kweon, Sun-Seog, Lee, Young-Hoon, Choi, Seong-Woo, Ryu, So-Yeon, Nam, Hae-Sung, Park, Kyeong-Soo, Kim, Hye-Yeon, Shin, Min-Ho
Format: Article
Language:English
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Original Research
내과학
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Summary:Previous observational studies presented a positive association between alcohol and atrial fibrillation (AF). However, previous studies using genetic polymorphisms on the causal relationship between alcohol consumption and AF have reported conflicting results. This study aimed to evaluate the causality between alcohol consumption and AF using the aldehyde dehydrogenase 2 ( ) rs671 polymorphism, which is the genetic variant with the most potent effect on drinking behavior. A total of 8,964 participants from the Dong-gu Study were included in the present study. The causal association between alcohol consumption and AF was evaluated through a Mendelian randomization (MR) analysis using the rs671 polymorphism as an instrumental variable. No significant relationship between alcohol consumption and AF was found in the observational analysis. However, the genetic analysis using the polymorphism showed a significant association in men. In the MR analysis, genetically predicted daily alcohol consumption was positively related to AF. MR analysis revealed a significant association between the amount of alcohol consumption and AF, which suggests that the association may be causal.
ISSN:1738-5520
1738-5555
DOI:10.4070/KCJ.2021.0269