Effects of interleukin-17 inhibitors on hepatic fibrosis index in patients with psoriasis and metabolic dysfunction-associated fatty liver disease: Directed acyclic graphs

[...]suppression of IL-17 inhibits activation of hepatic stellate cells and collagen production in vitro [11]. [...]treatment with anti-IL-17 antibody improved hepatic fibrosis in a NASH mice model [12]. IL-17 signaling promotes apoptosis of human megakaryocyte cells, and neutralization of IL-17 up-...

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Published in:Clinical and molecular hepatology 2022, 28(2), , pp.269-272
Main Authors: Takamura, Saori, Teraki, Yuichi, Katayama, Eri, Kawaguchi, Takumi, Kawaguchi, Machiko, Nakano, Dan, Tsutsumi, Tsubasa, Nagoshi, Sumiko, Nakama, Takekuni, Torimura, Takuji
Format: Article
Language:English
Subjects:
Alcohol use
Apoptosis
Body fat
Cytokines
Decision trees
Humans
Inflammation
Insulin resistance
Interleukin-17
Letter to the Editor
Liver
Liver cirrhosis
Liver Cirrhosis - complications
Liver diseases
liver fibrosis
metabolic diseases
Metabolism
Neutrophils
non-alcoholic fatty liver disease
Non-alcoholic Fatty Liver Disease - complications
Non-alcoholic Fatty Liver Disease - drug therapy
Pathogenesis
Psoriasis
Psoriasis - complications
Psoriasis - drug therapy
R&D
Research & development
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Summary:[...]suppression of IL-17 inhibits activation of hepatic stellate cells and collagen production in vitro [11]. [...]treatment with anti-IL-17 antibody improved hepatic fibrosis in a NASH mice model [12]. IL-17 signaling promotes apoptosis of human megakaryocyte cells, and neutralization of IL-17 up-regulates anti-apoptotic Bcl-2 protein in megakaryocyte cells [14]. [...]IL-17 exacerbates hepatic inflammation through regulatory T cell-mediated responses in a mouse model of NAFLD [9]. [...]this is a two-center retrospective study with small sample size. [...]study should be designed as a multi-center prospective study with imaging modalities for hepatic fibrosis. [...]IL-17i may improve hepatic fibrosis through the regulation of platelet count and hepatic inflammation.
ISSN:2287-2728
2287-285X
DOI:10.3350/cmh.2022.0040