Loading…

Recent progress (2015–2020) in the investigation of the pharmacological effects and mechanisms of ginsenoside Rb1, a main active ingredient in Panax ginseng Meyer

Ginsenoside Rb1 (Rb1), one of the most important ingredients in Panax ginseng Meyer, has been confirmed to have favorable activities, including reducing antioxidative stress, inhibiting inflammation, regulating cell autophagy and apoptosis, affecting sugar and lipid metabolism, and regulating variou...

Full description

Saved in:
Bibliographic Details
Published in:Journal of ginseng research 2022, 46(1), , pp.39-53
Main Authors: Lin, Zuan, Xie, Rongfang, Zhong, Chenhui, Huang, Jianyong, Shi, Peiying, Yao, Hong
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c558t-9a5a505c63ae0aee54a4c77787a23cfc05f4ad1c356389a6af5703a9fb3882883
cites cdi_FETCH-LOGICAL-c558t-9a5a505c63ae0aee54a4c77787a23cfc05f4ad1c356389a6af5703a9fb3882883
container_end_page 53
container_issue 1
container_start_page 39
container_title Journal of ginseng research
container_volume 46
creator Lin, Zuan
Xie, Rongfang
Zhong, Chenhui
Huang, Jianyong
Shi, Peiying
Yao, Hong
description Ginsenoside Rb1 (Rb1), one of the most important ingredients in Panax ginseng Meyer, has been confirmed to have favorable activities, including reducing antioxidative stress, inhibiting inflammation, regulating cell autophagy and apoptosis, affecting sugar and lipid metabolism, and regulating various cytokines. This study reviewed the recent progress on the pharmacological effects and mechanisms of Rb1 against cardiovascular and nervous system diseases, diabetes, and their complications, especially those related to neurodegenerative diseases, myocardial ischemia, hypoxia injury, and traumatic brain injury. This review retrieved articles from PubMed and Web of Science that were published from 2015 to 2020. The molecular targets or pathways of the effects of Rb1 on these diseases are referring to HMGB1, GLUT4, 11β-HSD1, ERK, Akt, Notch, NF-κB, MAPK, PPAR-γ, TGF-β1/Smad pathway, PI3K/mTOR pathway, Nrf2/HO-1 pathway, Nrf2/ARE pathway, and MAPK/NF-κB pathway. The potential effects of Rb1 and its possible mechanisms against diseases were further predicted via Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and disease ontology semantic and enrichment (DOSE) analyses with the reported targets. This study provides insights into the therapeutic effects of Rb1 and its mechanisms against diseases, which is expected to help in promoting the drug development of Rb1 and its clinical applications. [Display omitted]
doi_str_mv 10.1016/j.jgr.2021.07.008
format article
fullrecord <record><control><sourceid>nurimedia_nrf_k</sourceid><recordid>TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_9950041</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><nurid>NODE11055818</nurid><els_id>S1226845321001123</els_id><doaj_id>oai_doaj_org_article_f74c3f2cbb924b4c885ef2deb7d09631</doaj_id><sourcerecordid>NODE11055818</sourcerecordid><originalsourceid>FETCH-LOGICAL-c558t-9a5a505c63ae0aee54a4c77787a23cfc05f4ad1c356389a6af5703a9fb3882883</originalsourceid><addsrcrecordid>eNp9Uttu1DAQjRCIlsIH8JYXpFZiF1_i2BFSpaoUqFQoqsqzNXHGWW-TeLGzK_rGP_ALfBlfgrO7qtQXnkYan3NmPOdk2WtK5pTQ8t1yvmzDnBFG50TOCVFPskNGKj4rqkI-zQ4pY-VMFYIfZC9iXBJSSiaL59kBF0QoycrD7M8NGhzGfBV8GzDG_JgRKv7--p1UyUnuhnxcYCobjKNrYXR-yL3dNlcLCD0Y3_nWGehytBbNGHMYmrxHs4DBxT5O6NYNEQcfXYP5TU3f5pD3kKTBjG4zqafRjZvWSM1vMMDPPaXNv-A9hpfZMwtdxFf7epR9_3hxe_55dnX96fL87GpmhFDjrAIB6WOm5IAEEEUBhZFSKgmMG2uIsAU01HBRclVBCVZIwqGyNVeKKcWPspOd7hCsvjNOe3Db2np9F_TZze2lripBSEET9nKHbTws9Sq4HsL9lrBt-NBqCKMzHWorC8MtM3VdsaIujFICLWuwlg2pSj5pne60Vuu6x2YyJED3SPTxy-AWaaeNVlJwwSaB471A8D_WySrdu2iw62BAv46alYwxWRUVT1C6g5rgYwxoH8ZQoqdU6aVOqdJTqjSROqUqcd7s77JO2GQVPJC-Xn-4oJSk-9MJ936Hw2TSxmHQ0SRbTWKEFI10GfefKf8AdrziAw</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2622279493</pqid></control><display><type>article</type><title>Recent progress (2015–2020) in the investigation of the pharmacological effects and mechanisms of ginsenoside Rb1, a main active ingredient in Panax ginseng Meyer</title><source>ScienceDirect Journals</source><source>PubMed Central</source><creator>Lin, Zuan ; Xie, Rongfang ; Zhong, Chenhui ; Huang, Jianyong ; Shi, Peiying ; Yao, Hong</creator><creatorcontrib>Lin, Zuan ; Xie, Rongfang ; Zhong, Chenhui ; Huang, Jianyong ; Shi, Peiying ; Yao, Hong</creatorcontrib><description>Ginsenoside Rb1 (Rb1), one of the most important ingredients in Panax ginseng Meyer, has been confirmed to have favorable activities, including reducing antioxidative stress, inhibiting inflammation, regulating cell autophagy and apoptosis, affecting sugar and lipid metabolism, and regulating various cytokines. This study reviewed the recent progress on the pharmacological effects and mechanisms of Rb1 against cardiovascular and nervous system diseases, diabetes, and their complications, especially those related to neurodegenerative diseases, myocardial ischemia, hypoxia injury, and traumatic brain injury. This review retrieved articles from PubMed and Web of Science that were published from 2015 to 2020. The molecular targets or pathways of the effects of Rb1 on these diseases are referring to HMGB1, GLUT4, 11β-HSD1, ERK, Akt, Notch, NF-κB, MAPK, PPAR-γ, TGF-β1/Smad pathway, PI3K/mTOR pathway, Nrf2/HO-1 pathway, Nrf2/ARE pathway, and MAPK/NF-κB pathway. The potential effects of Rb1 and its possible mechanisms against diseases were further predicted via Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and disease ontology semantic and enrichment (DOSE) analyses with the reported targets. This study provides insights into the therapeutic effects of Rb1 and its mechanisms against diseases, which is expected to help in promoting the drug development of Rb1 and its clinical applications. [Display omitted]</description><identifier>ISSN: 1226-8453</identifier><identifier>EISSN: 2093-4947</identifier><identifier>DOI: 10.1016/j.jgr.2021.07.008</identifier><identifier>PMID: 35058726</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>Effect mechanism ; Ginsenoside Rb1 ; Perspectives ; Pharmacological effect ; Review ; 기타의약학</subject><ispartof>Journal of Ginseng Research, 2022, 46(1), , pp.39-53</ispartof><rights>2021</rights><rights>2021 The Korean Society of Ginseng. Publishing services by Elsevier B.V. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c558t-9a5a505c63ae0aee54a4c77787a23cfc05f4ad1c356389a6af5703a9fb3882883</citedby><cites>FETCH-LOGICAL-c558t-9a5a505c63ae0aee54a4c77787a23cfc05f4ad1c356389a6af5703a9fb3882883</cites><orcidid>0000-0003-3826-934X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8753521/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1226845321001123$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,3549,27924,27925,45780,53791,53793</link.rule.ids><backlink>$$Uhttps://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002829732$$DAccess content in National Research Foundation of Korea (NRF)$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Zuan</creatorcontrib><creatorcontrib>Xie, Rongfang</creatorcontrib><creatorcontrib>Zhong, Chenhui</creatorcontrib><creatorcontrib>Huang, Jianyong</creatorcontrib><creatorcontrib>Shi, Peiying</creatorcontrib><creatorcontrib>Yao, Hong</creatorcontrib><title>Recent progress (2015–2020) in the investigation of the pharmacological effects and mechanisms of ginsenoside Rb1, a main active ingredient in Panax ginseng Meyer</title><title>Journal of ginseng research</title><description>Ginsenoside Rb1 (Rb1), one of the most important ingredients in Panax ginseng Meyer, has been confirmed to have favorable activities, including reducing antioxidative stress, inhibiting inflammation, regulating cell autophagy and apoptosis, affecting sugar and lipid metabolism, and regulating various cytokines. This study reviewed the recent progress on the pharmacological effects and mechanisms of Rb1 against cardiovascular and nervous system diseases, diabetes, and their complications, especially those related to neurodegenerative diseases, myocardial ischemia, hypoxia injury, and traumatic brain injury. This review retrieved articles from PubMed and Web of Science that were published from 2015 to 2020. The molecular targets or pathways of the effects of Rb1 on these diseases are referring to HMGB1, GLUT4, 11β-HSD1, ERK, Akt, Notch, NF-κB, MAPK, PPAR-γ, TGF-β1/Smad pathway, PI3K/mTOR pathway, Nrf2/HO-1 pathway, Nrf2/ARE pathway, and MAPK/NF-κB pathway. The potential effects of Rb1 and its possible mechanisms against diseases were further predicted via Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and disease ontology semantic and enrichment (DOSE) analyses with the reported targets. This study provides insights into the therapeutic effects of Rb1 and its mechanisms against diseases, which is expected to help in promoting the drug development of Rb1 and its clinical applications. [Display omitted]</description><subject>Effect mechanism</subject><subject>Ginsenoside Rb1</subject><subject>Perspectives</subject><subject>Pharmacological effect</subject><subject>Review</subject><subject>기타의약학</subject><issn>1226-8453</issn><issn>2093-4947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNp9Uttu1DAQjRCIlsIH8JYXpFZiF1_i2BFSpaoUqFQoqsqzNXHGWW-TeLGzK_rGP_ALfBlfgrO7qtQXnkYan3NmPOdk2WtK5pTQ8t1yvmzDnBFG50TOCVFPskNGKj4rqkI-zQ4pY-VMFYIfZC9iXBJSSiaL59kBF0QoycrD7M8NGhzGfBV8GzDG_JgRKv7--p1UyUnuhnxcYCobjKNrYXR-yL3dNlcLCD0Y3_nWGehytBbNGHMYmrxHs4DBxT5O6NYNEQcfXYP5TU3f5pD3kKTBjG4zqafRjZvWSM1vMMDPPaXNv-A9hpfZMwtdxFf7epR9_3hxe_55dnX96fL87GpmhFDjrAIB6WOm5IAEEEUBhZFSKgmMG2uIsAU01HBRclVBCVZIwqGyNVeKKcWPspOd7hCsvjNOe3Db2np9F_TZze2lripBSEET9nKHbTws9Sq4HsL9lrBt-NBqCKMzHWorC8MtM3VdsaIujFICLWuwlg2pSj5pne60Vuu6x2YyJED3SPTxy-AWaaeNVlJwwSaB471A8D_WySrdu2iw62BAv46alYwxWRUVT1C6g5rgYwxoH8ZQoqdU6aVOqdJTqjSROqUqcd7s77JO2GQVPJC-Xn-4oJSk-9MJ936Hw2TSxmHQ0SRbTWKEFI10GfefKf8AdrziAw</recordid><startdate>20220101</startdate><enddate>20220101</enddate><creator>Lin, Zuan</creator><creator>Xie, Rongfang</creator><creator>Zhong, Chenhui</creator><creator>Huang, Jianyong</creator><creator>Shi, Peiying</creator><creator>Yao, Hong</creator><general>Elsevier B.V</general><general>고려인삼학회</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>DBRKI</scope><scope>TDB</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><scope>ACYCR</scope><orcidid>https://orcid.org/0000-0003-3826-934X</orcidid></search><sort><creationdate>20220101</creationdate><title>Recent progress (2015–2020) in the investigation of the pharmacological effects and mechanisms of ginsenoside Rb1, a main active ingredient in Panax ginseng Meyer</title><author>Lin, Zuan ; Xie, Rongfang ; Zhong, Chenhui ; Huang, Jianyong ; Shi, Peiying ; Yao, Hong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c558t-9a5a505c63ae0aee54a4c77787a23cfc05f4ad1c356389a6af5703a9fb3882883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Effect mechanism</topic><topic>Ginsenoside Rb1</topic><topic>Perspectives</topic><topic>Pharmacological effect</topic><topic>Review</topic><topic>기타의약학</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Zuan</creatorcontrib><creatorcontrib>Xie, Rongfang</creatorcontrib><creatorcontrib>Zhong, Chenhui</creatorcontrib><creatorcontrib>Huang, Jianyong</creatorcontrib><creatorcontrib>Shi, Peiying</creatorcontrib><creatorcontrib>Yao, Hong</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>DBPIA - 디비피아</collection><collection>DBPIA</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><collection>Korean Citation Index</collection><jtitle>Journal of ginseng research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Zuan</au><au>Xie, Rongfang</au><au>Zhong, Chenhui</au><au>Huang, Jianyong</au><au>Shi, Peiying</au><au>Yao, Hong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recent progress (2015–2020) in the investigation of the pharmacological effects and mechanisms of ginsenoside Rb1, a main active ingredient in Panax ginseng Meyer</atitle><jtitle>Journal of ginseng research</jtitle><date>2022-01-01</date><risdate>2022</risdate><volume>46</volume><issue>1</issue><spage>39</spage><epage>53</epage><pages>39-53</pages><issn>1226-8453</issn><eissn>2093-4947</eissn><abstract>Ginsenoside Rb1 (Rb1), one of the most important ingredients in Panax ginseng Meyer, has been confirmed to have favorable activities, including reducing antioxidative stress, inhibiting inflammation, regulating cell autophagy and apoptosis, affecting sugar and lipid metabolism, and regulating various cytokines. This study reviewed the recent progress on the pharmacological effects and mechanisms of Rb1 against cardiovascular and nervous system diseases, diabetes, and their complications, especially those related to neurodegenerative diseases, myocardial ischemia, hypoxia injury, and traumatic brain injury. This review retrieved articles from PubMed and Web of Science that were published from 2015 to 2020. The molecular targets or pathways of the effects of Rb1 on these diseases are referring to HMGB1, GLUT4, 11β-HSD1, ERK, Akt, Notch, NF-κB, MAPK, PPAR-γ, TGF-β1/Smad pathway, PI3K/mTOR pathway, Nrf2/HO-1 pathway, Nrf2/ARE pathway, and MAPK/NF-κB pathway. The potential effects of Rb1 and its possible mechanisms against diseases were further predicted via Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and disease ontology semantic and enrichment (DOSE) analyses with the reported targets. This study provides insights into the therapeutic effects of Rb1 and its mechanisms against diseases, which is expected to help in promoting the drug development of Rb1 and its clinical applications. [Display omitted]</abstract><pub>Elsevier B.V</pub><pmid>35058726</pmid><doi>10.1016/j.jgr.2021.07.008</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0003-3826-934X</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1226-8453
ispartof Journal of Ginseng Research, 2022, 46(1), , pp.39-53
issn 1226-8453
2093-4947
language eng
recordid cdi_nrf_kci_oai_kci_go_kr_ARTI_9950041
source ScienceDirect Journals; PubMed Central
subjects Effect mechanism
Ginsenoside Rb1
Perspectives
Pharmacological effect
Review
기타의약학
title Recent progress (2015–2020) in the investigation of the pharmacological effects and mechanisms of ginsenoside Rb1, a main active ingredient in Panax ginseng Meyer
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T04%3A03%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-nurimedia_nrf_k&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Recent%20progress%20(2015%E2%80%932020)%20in%20the%20investigation%20of%20the%20pharmacological%20effects%20and%20mechanisms%20of%20ginsenoside%20Rb1,%20a%20main%20active%20ingredient%20in%20Panax%20ginseng%20Meyer&rft.jtitle=Journal%20of%20ginseng%20research&rft.au=Lin,%20Zuan&rft.date=2022-01-01&rft.volume=46&rft.issue=1&rft.spage=39&rft.epage=53&rft.pages=39-53&rft.issn=1226-8453&rft.eissn=2093-4947&rft_id=info:doi/10.1016/j.jgr.2021.07.008&rft_dat=%3Cnurimedia_nrf_k%3ENODE11055818%3C/nurimedia_nrf_k%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c558t-9a5a505c63ae0aee54a4c77787a23cfc05f4ad1c356389a6af5703a9fb3882883%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2622279493&rft_id=info:pmid/35058726&rft_nurid=NODE11055818&rfr_iscdi=true