Intraoperative Radiotherapy for Resectable Pancreatic Cancer Using a Low-Energy X-Ray Source: Postoperative Complications and Early Outcomes

We evaluated the safety, feasibility, and early treatment outcomes of intraoperative radiotherapy (IORT) using a low-energy X-ray source. Patients with resectable pancreatic cancer were enrolled in this single-institution, prospective, single-arm, phase II trial. Patients underwent surgery and IORT...

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Bibliographic Details
Published in:Yonsei medical journal 2022, 63(5), , pp.405-412
Main Authors: Cho, Yeona, Kim, Jun Won, Kim, Hyung Sun, Park, Joon Seong, Lee, Ik Jae
Format: Article
Language:English
Subjects:
Combined Modality Therapy
Humans
Neoplasm Recurrence, Local
Original
Pancreatic Neoplasms
Pancreatic Neoplasms - radiotherapy
Pancreatic Neoplasms - surgery
Postoperative Complications
Prospective Studies
Radiotherapy, Adjuvant
X-Rays
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Summary:We evaluated the safety, feasibility, and early treatment outcomes of intraoperative radiotherapy (IORT) using a low-energy X-ray source. Patients with resectable pancreatic cancer were enrolled in this single-institution, prospective, single-arm, phase II trial. Patients underwent surgery and IORT with 10 Gy prescribed at a 5-mm depth from the tumor bed using a 50 kV X-ray source (Intrabeam, Carl Zeiss). Six cycles of adjuvant gemcitabine-based chemotherapy were administered 8-12 weeks after surgery. A total of 41 patients were included. Thirty-one patients (75.6%) underwent wide R0 resection, while 5 (12.2%) underwent R1 resection and 5 (12.2%) underwent narrow R0 resection (retroperitoneal margin
ISSN:0513-5796
1976-2437
DOI:10.3349/ymj.2022.63.5.405