Association of young age and male sex with primary sclerosing cholangitis in Taiwanese patients with inflammatory bowel disease

• Published in: Intestinal research 2022, 20(2), , pp.224-230
• Main Authors: Weng, Meng-Tzu, Shih, I-Lun, Tung, Chien-Chih, Leong, Yew-Loong, Shieh, Ming-Jium, Wang, Cheng-Yi, Wong, Jau-Min, Ni, Yen-Hsuan, Wei, Shu-Chen
• Format: Article
• Language: English
• Subjects: inflammatory bowel disease; Original; primary sclerosing cholangitis; ulcerative colitis; 내과학
• ISSN: 1598-9100; 2288-1956
• DOI: 10.5217/ir.2021.00042

Background/Aims: Primary sclerosing cholangitis (PSC) is associated with inflammatory bowel disease (IBD). We aimed to evaluate the prevalence, clinical manifestation, and outcomes of PSC in Taiwanese patients with IBD. Methods: This retrospective study enrolled patients with IBD admitted from January 1, 1996, to December 31, 2018, to National Taiwan University Hospital. A case-matched analysis was performed comparing patients with IBD with and without PSC according to age, sex, and time of admission, with ratios of 1:4 and 1:2 in the adult and pediatric groups, respectively.Results: In total, 763 patients with IBD were enrolled, 12 of whom were also diagnosed with PSC (1.57%). All these patients had ulcerative colitis (UC). A greater incidence of IBD with PSC was observed in younger patients than in older patients. Male sex was a risk factor for PSC in pediatric patients with IBD (P=0.015); 75% of these patients were diagnosed with PSC along with or after the diagnosis of UC. There was no significant difference in colitis extent and severity between the groups; however, a higher proportion of rectal sparing was observed in patients with PSC (P=0.001). There was no significant difference in cancer development between the groups (P=0.679). Conclusions: A 1.57% prevalence of PSC was observed in Taiwanese patients with IBD. The majority of patients with IBD and PSC were men and were diagnosed at a younger age. Hence, routine evaluation of biliary enzymes and liver imaging is recommended in young male patients with IBD.