Increased Risk of Cancer after Cholecystectomy: A Nationwide Cohort Study in Korea including 123,295 Patients

Contradictory findings on the association between cholecystectomy and cancer have been reported. We aimed to investigate the risk of all types of cancers or site-specific cancers in patients who underwent cholecystectomy using a nationwide dataset. Subjects who underwent cholecystectomy from January...

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Bibliographic Details
Published in:Gut and liver 2022, 16(3), , pp.465-473
Main Authors: Choi, Yoon Jin, Jin, Eun Hyo, Lim, Joo Hyun, Shin, Cheol Min, Kim, Nayoung, Han, Kyungdo, Lee, Dong Ho
Format: Article
Language:English
Subjects:
cholecystectomy
Cholecystectomy - adverse effects
Cohort Studies
Female
gallbladder
Humans
Incidence
Male
neoplasms
Neoplasms - epidemiology
Neoplasms - etiology
Original
Republic of Korea - epidemiology
Retrospective Studies
Risk Factors
내과학
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Summary:Contradictory findings on the association between cholecystectomy and cancer have been reported. We aimed to investigate the risk of all types of cancers or site-specific cancers in patients who underwent cholecystectomy using a nationwide dataset. Subjects who underwent cholecystectomy from January 1, 2007, to December 31, 2014, who were older than 20 years and who underwent an initial baseline health check-up within 2 years were enrolled. Those who were diagnosed with any type of cancer before the enrollment or within 1 year after enrollment were excluded. Ultimately, patients (n=123,295) who underwent cholecystectomy and age/sex matched population (n=123,295) were identified from the database of the Korean National Health Insurance Service. The hazard ratio (HR) and 95% confidence interval (CI) for cancer were estimated, and Cox regression analysis was performed. The incidence of cancer in the cholecystectomy group was 9.56 per 1,000 person-years and that in the control group was 7.95 per 1,000 person-years. Patients who underwent cholecystectomy showed an increased risk of total cancer (adjusted HR, 1.19; 95% CI, 1.15 to 1.24; p
ISSN:1976-2283
2005-1212
DOI:10.5009/gnl210009