Role of bicarbonate and volume therapy in the prevention of acute kidney injury in rhabdomyolysis: a retrospective propensity score-matched cohort study

Although bicarbonate has traditionally been used to treat patients with rhabdomyolysis at high risk of acute kidney injury (AKI), it is unclear whether this is beneficial. This study compared bicarbonate therapy to non-bicarbonate therapy for the prevention of AKI and mortality in rhabdomyolysis pat...

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Bibliographic Details
Published in:Kidney research and clinical practice 2022, 41(3), , pp.310-321
Main Authors: Kim, Hye Won, Kim, Sejoong, Ohn, Jung Hun, Kim, Nak-Hyun, Lee, Jongchan, Kim, Eun Sun, Lim, Yejee, Cho, Jae Ho, Park, Hee Sun, Ryu, Jiwon, Kim, Sun-Wook
Format: Article
Language:English
Subjects:
acute kidney injury
Original
rhabdomyolysis
sodium bicarbonate
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Summary:Although bicarbonate has traditionally been used to treat patients with rhabdomyolysis at high risk of acute kidney injury (AKI), it is unclear whether this is beneficial. This study compared bicarbonate therapy to non-bicarbonate therapy for the prevention of AKI and mortality in rhabdomyolysis patients. In a propensity score-matched cohort study, patients with a creatine kinase (CK) level of >1,000 U/L during hospitalization were divided into bicarbonate and non-bicarbonate groups. Patients were subgrouped based on low-volume (
ISSN:2211-9132
2211-9140
DOI:10.23876/j.krcp.21.093