The Efficacy and Safety of Clonazepam in Patients with Anxiety Disorder Taking Newer Antidepressants: A Multicenter Naturalistic Study

This study compared the efficacy and tolerability of clonazepam with other benzodiazepines in patients with anxiety disorders. Inclusion criteria were as follows: age >20 years, diagnosis of anxiety disorder according to the Diagnostic and Statistical Manual of Mental Disorders 4th edition, text...

Full description

Saved in:
Bibliographic Details
Published in:Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology 2016, 14(2), , pp.177-183
Main Authors: Wang, Sheng-Min, Kim, Jung-Bum, Sakong, Jeong Kyu, Suh, Ho-Suk, Oh, Kang Seob, Woo, Jong-Min, Yoo, Sang-Woo, Lee, Sang Min, Lee, Sang-Yeol, Lim, Se-Won, Cho, Seong Jin, Chee, Ik-Seung, Chae, Jeong-Ho, Hong, Jin Pyo, Lee, Kyoung-Uk
Format: Article
Language:English
Subjects:
Original
정신과학
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study compared the efficacy and tolerability of clonazepam with other benzodiazepines in patients with anxiety disorders. Inclusion criteria were as follows: age >20 years, diagnosis of anxiety disorder according to the Diagnostic and Statistical Manual of Mental Disorders 4th edition, text revision (DSM-IV-TR) criteria, taking only one type of antidepressant, and prescribed one of three oral benzodiazepines (alprazolam, clonazepam, or lorazepam). At baseline and week 6, clinical benefit was evaluated using the Clinical Global Impression-Severity Scale (CGI-S), Clinical Global Impression-Anxiety Scale (CGI-anxiety), and Clinical Global Impression-Sleep Scale (CGI-sleep). Among 180 patients, no differences in demographic characteristics among the three benzodiazepine groups were noted. After six weeks of treatment, all benzodiazepine groups showed significant improvements in CGI-S, CGI-anxiety, and CGI-sleep scores (p
ISSN:1738-1088
2093-4327
DOI:10.9758/cpn.2016.14.2.177