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Serum Levels of Growth Factors in Alcohol-dependent Patients according to Comorbid Depressive Symptoms
This study aims to reveal the relationship of depression with growth factors such as brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and insulin-like growth factor-1 (IGF-1) in inpatients diagnosed with alcohol dependence, and to identify candidate growth factors as biological m...
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Published in: | Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology 2016, 14(1), , pp.43-48 |
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container_title | Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology |
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creator | Han, Changwoo Ahn, Donghyun Hahm, Woong Nam, Junghyun Park, Yongchon Lim, Seulgi Kim, Dai-Jin |
description | This study aims to reveal the relationship of depression with growth factors such as brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and insulin-like growth factor-1 (IGF-1) in inpatients diagnosed with alcohol dependence, and to identify candidate growth factors as biological markers to indicate the comorbid of alcohol dependence and depression.
This study examined demographic factors in 45 alcohol-dependent patients. The ADS (Korean version of the Alcohol Dependence Scale) and BDI (Korean version of Beck's Depression Inventory) were used. BDNF, NGF, and IGF-1 were measured through ELISA.
The average drinking quantity and the ADS score were significantly more severe in alcohol-dependent patients with depression than in those without depression. Linearly comparing BDNF, NGF, and IGF-1 with BDI values, IGF-1 was the growth factor significantly correlated with BDI scores. BDI scores were significantly correlated with ADS scores. IGF-1 was significantly higher in alcohol-dependent patients with depression. Alcohol-dependent patients with depression had greater alcohol use and more severe ADS scores. BDNF and NGF showed no significant difference between alcohol-dependent patients with and without depression, but IGF-1 was significantly higher in those with than in those without depression.
IGF-1 was found to be associated with depression in alcohol-dependent patients, suggesting that IGF-1 in alcohol- dependent patients could be an important biomarker to indicate whether alcohol-dependence is accompanied by depression. |
doi_str_mv | 10.9758/cpn.2016.14.1.43 |
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This study examined demographic factors in 45 alcohol-dependent patients. The ADS (Korean version of the Alcohol Dependence Scale) and BDI (Korean version of Beck's Depression Inventory) were used. BDNF, NGF, and IGF-1 were measured through ELISA.
The average drinking quantity and the ADS score were significantly more severe in alcohol-dependent patients with depression than in those without depression. Linearly comparing BDNF, NGF, and IGF-1 with BDI values, IGF-1 was the growth factor significantly correlated with BDI scores. BDI scores were significantly correlated with ADS scores. IGF-1 was significantly higher in alcohol-dependent patients with depression. Alcohol-dependent patients with depression had greater alcohol use and more severe ADS scores. BDNF and NGF showed no significant difference between alcohol-dependent patients with and without depression, but IGF-1 was significantly higher in those with than in those without depression.
IGF-1 was found to be associated with depression in alcohol-dependent patients, suggesting that IGF-1 in alcohol- dependent patients could be an important biomarker to indicate whether alcohol-dependence is accompanied by depression.</description><identifier>ISSN: 1738-1088</identifier><identifier>EISSN: 2093-4327</identifier><identifier>DOI: 10.9758/cpn.2016.14.1.43</identifier><identifier>PMID: 26792039</identifier><language>eng</language><publisher>Korea (South): Korean College of Neuropsychopharmacology</publisher><subject>Original ; 정신과학</subject><ispartof>Clinical Psychopharmacology and Neuroscience, 2016, 14(1), , pp.43-48</ispartof><rights>Copyright © 2016, Korean College of Neuropsychopharmacology 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-288598c64ad48a9411afef3d3e5c2bea35ad2f84e17bcf5516f9cab9be792d8d3</citedby><cites>FETCH-LOGICAL-c429t-288598c64ad48a9411afef3d3e5c2bea35ad2f84e17bcf5516f9cab9be792d8d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730941/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730941/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26792039$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002080626$$DAccess content in National Research Foundation of Korea (NRF)$$Hfree_for_read</backlink></links><search><creatorcontrib>Han, Changwoo</creatorcontrib><creatorcontrib>Ahn, Donghyun</creatorcontrib><creatorcontrib>Hahm, Woong</creatorcontrib><creatorcontrib>Nam, Junghyun</creatorcontrib><creatorcontrib>Park, Yongchon</creatorcontrib><creatorcontrib>Lim, Seulgi</creatorcontrib><creatorcontrib>Kim, Dai-Jin</creatorcontrib><title>Serum Levels of Growth Factors in Alcohol-dependent Patients according to Comorbid Depressive Symptoms</title><title>Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology</title><addtitle>Clin Psychopharmacol Neurosci</addtitle><description>This study aims to reveal the relationship of depression with growth factors such as brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and insulin-like growth factor-1 (IGF-1) in inpatients diagnosed with alcohol dependence, and to identify candidate growth factors as biological markers to indicate the comorbid of alcohol dependence and depression.
This study examined demographic factors in 45 alcohol-dependent patients. The ADS (Korean version of the Alcohol Dependence Scale) and BDI (Korean version of Beck's Depression Inventory) were used. BDNF, NGF, and IGF-1 were measured through ELISA.
The average drinking quantity and the ADS score were significantly more severe in alcohol-dependent patients with depression than in those without depression. Linearly comparing BDNF, NGF, and IGF-1 with BDI values, IGF-1 was the growth factor significantly correlated with BDI scores. BDI scores were significantly correlated with ADS scores. IGF-1 was significantly higher in alcohol-dependent patients with depression. Alcohol-dependent patients with depression had greater alcohol use and more severe ADS scores. BDNF and NGF showed no significant difference between alcohol-dependent patients with and without depression, but IGF-1 was significantly higher in those with than in those without depression.
IGF-1 was found to be associated with depression in alcohol-dependent patients, suggesting that IGF-1 in alcohol- dependent patients could be an important biomarker to indicate whether alcohol-dependence is accompanied by depression.</description><subject>Original</subject><subject>정신과학</subject><issn>1738-1088</issn><issn>2093-4327</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNpVUU1v1DAQtRCIrkrvnJCPXJL6K4l9QVottFRaCUTL2XLscdc0iYOdXdR_j9stBebyNJr35s3oIfSWklp1jTy381QzQtuaiprWgr9AK0YUrwRn3Uu0oh2XFSVSnqCznH-QUly1QvHX6IS1nWKlXSF_DWk_4i0cYMg4enyZ4q9lhy-MXWLKOEx4Pdi4i0PlYIbJwbTgr2YJBTM21sbkwnSLl4g3cYypDw5_hDlBzuEA-Pp-nJc45jfolTdDhrMnPEXfLz7dbD5X2y-XV5v1trKCqaViUjZK2lYYJ6RRglLjwXPHobGsB8Mb45iXAmjXW980tPXKml71UP5x0vFT9P64d0pe39mgowmPeBv1XdLrbzdXWikpOlqoH47Ued-P4Gx5KJlBzymMJt0_Cv-fTGFX1hy06Dgpp_31mlP8uYe86DFkC8NgJoj7rGnXEqkaKmWhkiPVpphzAv9sQ4l-CFOXMPVDmJoKTbXgRfLu3_OeBX-i478BuxGdzw</recordid><startdate>20160229</startdate><enddate>20160229</enddate><creator>Han, Changwoo</creator><creator>Ahn, Donghyun</creator><creator>Hahm, Woong</creator><creator>Nam, Junghyun</creator><creator>Park, Yongchon</creator><creator>Lim, Seulgi</creator><creator>Kim, Dai-Jin</creator><general>Korean College of Neuropsychopharmacology</general><general>대한정신약물학회</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>ACYCR</scope></search><sort><creationdate>20160229</creationdate><title>Serum Levels of Growth Factors in Alcohol-dependent Patients according to Comorbid Depressive Symptoms</title><author>Han, Changwoo ; Ahn, Donghyun ; Hahm, Woong ; Nam, Junghyun ; Park, Yongchon ; Lim, Seulgi ; Kim, Dai-Jin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-288598c64ad48a9411afef3d3e5c2bea35ad2f84e17bcf5516f9cab9be792d8d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Original</topic><topic>정신과학</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Han, Changwoo</creatorcontrib><creatorcontrib>Ahn, Donghyun</creatorcontrib><creatorcontrib>Hahm, Woong</creatorcontrib><creatorcontrib>Nam, Junghyun</creatorcontrib><creatorcontrib>Park, Yongchon</creatorcontrib><creatorcontrib>Lim, Seulgi</creatorcontrib><creatorcontrib>Kim, Dai-Jin</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Korean Citation Index</collection><jtitle>Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Han, Changwoo</au><au>Ahn, Donghyun</au><au>Hahm, Woong</au><au>Nam, Junghyun</au><au>Park, Yongchon</au><au>Lim, Seulgi</au><au>Kim, Dai-Jin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum Levels of Growth Factors in Alcohol-dependent Patients according to Comorbid Depressive Symptoms</atitle><jtitle>Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology</jtitle><addtitle>Clin Psychopharmacol Neurosci</addtitle><date>2016-02-29</date><risdate>2016</risdate><volume>14</volume><issue>1</issue><spage>43</spage><epage>48</epage><pages>43-48</pages><issn>1738-1088</issn><eissn>2093-4327</eissn><abstract>This study aims to reveal the relationship of depression with growth factors such as brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and insulin-like growth factor-1 (IGF-1) in inpatients diagnosed with alcohol dependence, and to identify candidate growth factors as biological markers to indicate the comorbid of alcohol dependence and depression.
This study examined demographic factors in 45 alcohol-dependent patients. The ADS (Korean version of the Alcohol Dependence Scale) and BDI (Korean version of Beck's Depression Inventory) were used. BDNF, NGF, and IGF-1 were measured through ELISA.
The average drinking quantity and the ADS score were significantly more severe in alcohol-dependent patients with depression than in those without depression. Linearly comparing BDNF, NGF, and IGF-1 with BDI values, IGF-1 was the growth factor significantly correlated with BDI scores. BDI scores were significantly correlated with ADS scores. IGF-1 was significantly higher in alcohol-dependent patients with depression. Alcohol-dependent patients with depression had greater alcohol use and more severe ADS scores. BDNF and NGF showed no significant difference between alcohol-dependent patients with and without depression, but IGF-1 was significantly higher in those with than in those without depression.
IGF-1 was found to be associated with depression in alcohol-dependent patients, suggesting that IGF-1 in alcohol- dependent patients could be an important biomarker to indicate whether alcohol-dependence is accompanied by depression.</abstract><cop>Korea (South)</cop><pub>Korean College of Neuropsychopharmacology</pub><pmid>26792039</pmid><doi>10.9758/cpn.2016.14.1.43</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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title | Serum Levels of Growth Factors in Alcohol-dependent Patients according to Comorbid Depressive Symptoms |
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