Tryptophan Hydroxylase 2 G703T Polymorphism and the Temperament and Character in a Korean Population

• Published in: Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology 2010, 8(1), , pp.38-44
• Main Authors: 배승민, 김석주, Seong-Jin Cho, 조인희, Yu Jin Lee, 강승걸, Jung-Eun Choi, 이헌정
• Format: Article
• Language: English
• Subjects: 정신과학
• ISSN: 1738-1088; 2093-4327

Objective : We aimed to investigate the association between the tryptophan hydroxylase 2 (TPH2) G703T polymorphism and personality traits in a Korean population. The interaction between the TPH2 polymorphism and recent negative stressors in personality traits were also explored. Methods：The TPH2 G703T polymorphism was genotyped in 369 community-dwelling Koreans (143 male, 226 female, 42.6±13.7years old). The Temperament and Character Inventory (TCI) was self-administered. Face-to-face interviews, investigating negative life stressors within the last 6 months, were also performed. Results：There was no significant difference in TCI score among the three genotypes (93 G/G, 171 G/T, and 105 T/T subjects). There was also no significant difference in TCI scores between subjects experiencing stressors and those without stressors. However, there was a significant interaction between the TPH2 genotype and negative life stressors in the temperament of persistence (PS) (p=0.03); only subjects with the T/T genotype showed decreased PS with recent negative stressors. Conclusion：We could not find a direct association between the TPH2 G703T polymorphism and personality traits. However,our findings suggest that the TPH2 G703T polymorphism might influence PS by interacting with a recent negative stress experience. KCI Citation Count: 0