Multicenter, Open-Label Study to Evaluate the Effects of Methylphenidate-OROS(Concerta) on Cognitive Functions in Children with Attention Deficit Hyperactivity Disorder

Current models of ADHD are based on neuropsychological theories of impaired functioning of the frontal lobes, particularly the prefrontal cortex (PFC). Children with ADHD show improvements in performance on tests of executive function, attention, and vigilance following stimulant treatment. The aim...

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Bibliographic Details
Published in:Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology 2007, 5(1), , pp.31-37
Main Authors: Chulho Jung, Sangyong Choi, 정성훈, 송창진, 서완석, 정운선, 이종훈
Format: Article
Language:English
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정신과학
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Summary:Current models of ADHD are based on neuropsychological theories of impaired functioning of the frontal lobes, particularly the prefrontal cortex (PFC). Children with ADHD show improvements in performance on tests of executive function, attention, and vigilance following stimulant treatment. The aim of this study was to evaluate the effects of methylphenidate-OROS (MPH-OROS) on cognitive function and intellectual performance in Korean children with ADHD. Ninety-one elementary school children with ADHD (combined type), 6-12 years old, participated in the multicenter, 4-week open trial of MPH-OROS. Function was assessed using behavioral checklists, the KWISC-III, Continuous Performance Test (CPT), Trail-Making Test (TMT), and Wisconsin Card Sorting Test (WCST). In total, 83 subjects were analyzed using paired t-tests (repeated measures). After MPH-OROS treatment, significant improvements (p
ISSN:1738-1088
2093-4327