Optimizing probe design for an implantable perfusion and oxygenation sensor

In an effort to develop an implantable optical perfusion and oxygenation sensor, based on multiwavelength reflectance pulse oximetry, we investigate the effect of source detector separation and other source-detector characteristics to optimize the sensor s signal to background ratio using Monte Carl...

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Bibliographic Details
Published in:Biomedical optics express 2011-08, Vol.2 (8), p.2096
Main Authors: Akl, Tony J., Long, Ruiqi, McShane, Michael J., Ericson, M. Nance, Wilson, Mark A., Coté, Gerard L.
Format: Article
Language:English
Subjects:
60 APPLIED LIFE SCIENCES
ABSORPTION
APERTURES
BASIC BIOLOGICAL SCIENCES
BLOOD FLOW
BLOOD VESSELS
DESIGN
DYES
HEMOGLOBIN
IMPLANTS
IN VITRO
LIVER
MONITORING
MONTE CARLO METHOD
OPTIMIZATION
OXYGEN
PERFUSED TISSUES
PHANTOMS
POINT SOURCES
PROBES
SENSORS
SIMULATION
VISIBLE RADIATION
WAVELENGTHS
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Summary:In an effort to develop an implantable optical perfusion and oxygenation sensor, based on multiwavelength reflectance pulse oximetry, we investigate the effect of source detector separation and other source-detector characteristics to optimize the sensor s signal to background ratio using Monte Carlo (MC) based simulations and in vitro phantom studies. Separations in the range 0.45 to 1.25 mm were found to be optimal in the case of a point source. The numerical aperture (NA) of the source had no effect on the collected signal while the widening of the source spatial profile caused a shift in the optimal source-detector separation. Specifically, for a 4.5 mm flat beam and a 2.4 mm 2.5 mm photodetector, the optimal performance was found to be when the source and detector are adjacent to each other. These modeling results were confirmed by data collected from in vitro experiments on a liver phantom perfused with dye solutions mimicking the absorption properties of hemoglobin for different oxygenation states.
ISSN:2156-7085
2156-7085
DOI:10.1364/BOE.2.002096