Design, Total Chemical Synthesis, and X-Ray Structure of a Protein Having a Novel Linear-Loop Polypeptide Chain Topology

Lassoed at the other end: Original synthetic and structure determination methods were used to make a protein molecule with an unprecedented linear‐loop polypeptide chain topology, and to characterize its X‐ray structure.

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Bibliographic Details
Published in:Angewandte Chemie (International ed.) 2012-02, Vol.51 (6), p.1481-1486
Main Authors: Mandal, Kalyaneswar, Pentelute, Brad L., Bang, Duhee, Gates, Zachary P., Torbeev, Vladimir Yu, Kent, Stephen B. H.
Format: Article
Language:English
Subjects:
60 APPLIED LIFE SCIENCES
BASIC BIOLOGICAL SCIENCES
Chains
chemical ligation
DESIGN
Models, Chemical
Models, Molecular
Peptides - chemical synthesis
Peptides - chemistry
Plant Proteins - chemical synthesis
Plant Proteins - chemistry
POLYPEPTIDES
PROTEIN STRUCTURE
Protein Structure, Secondary
protein structures
PROTEINS
quasi racemates
RACEMATES
Stereoisomerism
SYNTHESIS
TOPOLOGY
X-rays
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Description
Summary:Lassoed at the other end: Original synthetic and structure determination methods were used to make a protein molecule with an unprecedented linear‐loop polypeptide chain topology, and to characterize its X‐ray structure.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201107846