Production of Sn-117m in the BR2 and HFIR Research Reactors

The BR2 reactor is a 100 MW{sub th} high-flux 'materials testing reactor', which produces a wide range of radioisotopes for various applications in nuclear medicine and industry. Tin-117m ({sup 117m}Sn), a promising radionuclide for therapeutic applications, and its production have been va...

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Bibliographic Details
Published in:Applied radiation and isotopes 2009-07, Vol.67 (7-8)
Main Authors: Ponsard, B., Srivastava, S., Garland, M., Knapp, R., Mirzadeh, S., Mausner, L.F.
Format: Article
Language:English
Subjects:
07 ISOTOPES AND RADIATION SOURCES
BONE MARROW
DOSIMETRY
ELECTRONS
ISOMERIC TRANSITIONS
NUCLEAR MEDICINE
PHOTONS
PRODUCTION
RADIOISOTOPES
radionuclides
radiopharmaceuticals
Sn-117M
TESTING
Tin-117m
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Summary:The BR2 reactor is a 100 MW{sub th} high-flux 'materials testing reactor', which produces a wide range of radioisotopes for various applications in nuclear medicine and industry. Tin-117m ({sup 117m}Sn), a promising radionuclide for therapeutic applications, and its production have been validated in the BR2 reactor. In contrast to therapeutic beta emitters, {sup 117m}Sn decays via isomeric transition with the emission of monoenergetic conversion electrons which are effective for metastatic bone pain palliation and radiosynovectomy with lesser damage to the bone marrow and the healthy tissues. Furthermore, the emitted gamma photons are ideal for imaging and dosimetry.
ISSN:0969-8043
1872-9800
DOI:10.1016/j.apradiso.2009.02.023