Crystallographic Recognition Controls Peptide Binding for Bio-Based Nanomaterials

The ability to control the size, shape, composition, and activity of nanomaterials presents a formidable challenge. Peptide approaches represent new avenues to achieve such control at the synthetic level; however, the critical interactions at the bio/nano interface that direct such precision remain...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the American Chemical Society 2011-08, Vol.133 (32), p.12346-12349
Main Authors: Coppage, Ryan, Slocik, Joseph M, Briggs, Beverly D, Frenkel, Anatoly I, Heinz, Hendrik, Naik, Rajesh R, Knecht, Marc R
Format: Article
Language:English
Subjects:
ACCURACY
Binding Sites
Crystallization
INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY
Molecular Dynamics Simulation
Nanoparticles - chemistry
Nanoparticles - ultrastructure
NANOSCIENCE AND NANOTECHNOLOGY
Palladium - chemistry
Particle Size
PEPTIDES
Peptides - chemistry
Protein Binding
SHAPE
SPECIFICITY
STABILIZATION
Surface Properties
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The ability to control the size, shape, composition, and activity of nanomaterials presents a formidable challenge. Peptide approaches represent new avenues to achieve such control at the synthetic level; however, the critical interactions at the bio/nano interface that direct such precision remain poorly understood. Here we present evidence to suggest that materials-directing peptides bind at specific time points during Pd nanoparticle (NP) growth, dictated by material crystallinity. As such surfaces are presented, rapid peptide binding occurs, resulting in the stabilization and size control of single-crystal NPs. Such specificity suggests that peptides could be engineered to direct the structure of nanomaterials at the atomic level, thus enhancing their activity.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja203726n