Production of ⁶¹Cu by the natZn(p,α) reaction: Improved separation and specific activity determination by titration with three chelators

In this study, the cyclotron-based production of positron-emitting 61Cu using the (p,α) reaction at 11.7 MeV was investigated starting from natural-zinc (natZn) and enriched 64Zn-foil targets, as well as its subsequent purification. For natZn, a combination of three resins were assessed to separate...

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Bibliographic Details
Published in:Journal of radioanalytical and nuclear chemistry 2015-09, Vol.6 (8)
Main Authors: Asad, Ali H., Smith, Suzanne V., Morandeau, Laurence M., Chan, Sun, Jeffery, Charmaine M., Price, Roger I.
Format: Article
Language:English
Subjects:
61Cu
64Zn
bifunctional chelators
Cu
ICP-MS
natZn
PARTICLE ACCELERATORS
RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
specific activity
Zn
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Summary:In this study, the cyclotron-based production of positron-emitting 61Cu using the (p,α) reaction at 11.7 MeV was investigated starting from natural-zinc (natZn) and enriched 64Zn-foil targets, as well as its subsequent purification. For natZn, a combination of three resins were assessed to separate 61Cu from contaminating 66,67,68Ga and natZn. The specific activity of the purified 61Cu determined using ICP-MS analysis ranged from 143.3 ± 14.3(SD) to 506.2 ± 50.6 MBq/µg while the titration method using p-SCN-Bn-DOTA, p-SCN-Bn-NOTA and diamsar gave variable results (4.7 ± 0.2–412.5 ± 15.3 MBq/µg), with diamsar lying closest to the ICP-MS values. Results suggest that the p-SCN-Bn-DOTA and p-SCN-Bn-NOTA titration methods are significantly affected by the presence of trace-metal contaminants.
ISSN:0236-5731
1588-2780