Cecal inoculum peritonitis: An alternative model for sepsis vascular dysfunction study

Sepsis is a life threatening condition that is characterized by the loss of vascular reactivity. The factor(s) responsible for the diminished vascular function seen in sepsis are not well understood. The purpose of this study was to characterize the vascular dysfunction from the rat cecal inoculum (...

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Bibliographic Details
Published in:Life sciences (1973) 2015-11, Vol.141 (C), p.108-118
Main Authors: Asano, Shinichi, Manne, Nandini D.P.K., Nandyala, Geeta, Ma, Bing, Selvaraj, Vellaisamy, Arvapalli, Ravikumar, Rice, Kevin M., R. Blough, Eric
Format: Article
Language:English
Subjects:
Acetylcholine - pharmacology
Animals
Cecum - microbiology
Cecum - pathology
Enzyme Inhibitors - pharmacology
K+ channel
KATP Channels - drug effects
Large-Conductance Calcium-Activated Potassium Channels - drug effects
Ligation
Lipopolysaccharides - pharmacology
Male
Muscle Contraction - drug effects
NG-Nitroarginine Methyl Ester - pharmacology
Nitric oxide
Peritonitis - microbiology
Peritonitis - pathology
Phenylephrine - pharmacology
Rats
Rats, Sprague-Dawley
Sepsis
Sepsis - microbiology
Sepsis - pathology
Vascular Diseases - microbiology
Vascular Diseases - pathology
Vascular inflammation
Vasoconstrictor Agents - pharmacology
Vasodilator Agents - pharmacology
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Summary:Sepsis is a life threatening condition that is characterized by the loss of vascular reactivity. The factor(s) responsible for the diminished vascular function seen in sepsis are not well understood. The purpose of this study was to characterize the vascular dysfunction from the rat cecal inoculum (CI) sepsis model using cecal ligation and puncture (CLP), and lipopolysaccharide (LPS) sepsis as reference models. Experiments were performed on isolated aorta from CI, CLP and LPS treated rats using a combination of pharmacological approaches. Phenylephrine (PE)-induced aortic contraction was significantly decreased in each model (p
ISSN:0024-3205
1879-0631
DOI:10.1016/j.lfs.2015.09.020