Evaluation of 72Se/72As generator and production of 72Se for supplying 72As as a potential PET imaging radionuclide

Positron-emitting 72As is the PET imaging counterpart for beta-emitting 77As. Its parent, no carrier added (n.c.a.) 72Se, was produced for a 72Se/72As generator by irradiating an enriched 7°Ge metal-graphite target via the 70Ge(α, 2 n)72Se reaction. Target dissolution used a fast, environmentally fr...

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Bibliographic Details
Published in:Applied radiation and isotopes 2019-01, Vol.143 (C), p.113-122
Main Authors: Feng, Yutian, Phipps, Michael D., Phelps, Tim E., Okoye, Nkemakonam C., Baumeister, Jakob E., Wycoff, Donald E., Dorman, Eric F., Wooten, A. Lake, Vlasenko, Vladislav, Berendzen, Ashley F., Wilbur, D. Scott, Hoffman, Timothy J., Cutler, Cathy S., Ketring, Alan R., Jurisson, Silvia S.
Format: Article
Language:English
Subjects:
70Ge target
72As
72Se
72Se/72As generator
Alpha irradiation
PARTICLE ACCELERATORS
Radiolabeling
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Summary:Positron-emitting 72As is the PET imaging counterpart for beta-emitting 77As. Its parent, no carrier added (n.c.a.) 72Se, was produced for a 72Se/72As generator by irradiating an enriched 7°Ge metal-graphite target via the 70Ge(α, 2 n)72Se reaction. Target dissolution used a fast, environmentally friendly method with 93% radioactivity recovery. Chromatographic parameters of the 72Se/72As generator were evaluated, the eluted n.c.a. 72As was characterized with a phantom imaging study, and the previously reported trithiol and aryl-dithiol ligand systems were radiolabeled with the separated n.c.a. 72As in high yield. •72Se production by α irradiation of 70Ge.•Simple Ge metal dissolution.•72Se/72As generator prepared and evaluated.
ISSN:0969-8043
1872-9800
DOI:10.1016/j.apradiso.2018.10.026