Insulator Nanostructure Desorption Ionization Mass Spectrometry

Surface-assisted laser desorption ionization (SALDI) is an approach for gas-phase ion generation for mass spectrometry using laser excitation on typically conductive or semiconductive nanostructures. Here, we introduce insulator nanostructure desorption ionization mass spectrometry (INDI-MS), a nano...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 2018-08, Vol.90 (16), p.9657-9661
Main Authors: Duncombe, Todd A, Raad, Markus De, Bowen, Benjamin P, Singh, Anup K, Northen, Trent R
Format: Article
Language:English
Subjects:
Analytical chemistry
Chemical vapor deposition
Chemistry
Desalination
Desorption
Excitation spectra
Hydrophobic surfaces
Ionization
Mass spectrometry
Nanostructure
Nanostructured materials
Organic chemistry
Peptides
Perfluoro compounds
Perfluoroalkyl & polyfluoroalkyl substances
Polymers
Self-assembly
Sensitivity analysis
Silanes
Spectroscopy
Substrates
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Description
Summary:Surface-assisted laser desorption ionization (SALDI) is an approach for gas-phase ion generation for mass spectrometry using laser excitation on typically conductive or semiconductive nanostructures. Here, we introduce insulator nanostructure desorption ionization mass spectrometry (INDI-MS), a nanostructured polymer substrate for SALDI-MS analysis of small molecules and peptides. INDI-MS surfaces are produced through the self-assembly of a perfluoroalkyl silsesquioxane nanostructures in a single chemical vapor deposition silanization-step. We find that surfaces formed from the perfluorooctyltrichlorosilane monomer assemble semielliptical features with a 10 nm height, diameters between 10 and 50 nm, and have attomole–femtomole sensitivities for selected analytes. Surfaces prepared with silanes that either lack the trichloro or perfluoro groups, lack sensitivity. Further, we demonstrate that hydrophobic INDI regions can be micropatterned onto hydrophilic surfaces to perform on-chip self-desalting in an array format.
ISSN:0003-2700
1520-6882
DOI:10.1021/acs.analchem.8b01989