Determination of 232Th and progeny in human reticuloendothelial tissues using alpha particle track autoradiographic microdosimetry from Thorotrast

Targeted alpha therapy has the properties of direct ionization, oxygen independency, high linear energy transfer, a short half-life, and minimal depth of penetration, which are advantageous in cancer treatment. This modified, inexpensive, high-resolution, autoradiographic study of 232 Th decay in a...

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Bibliographic Details
Published in:Journal of radioanalytical and nuclear chemistry 2018, Vol.318 (1), p.235-239
Main Authors: Schneider, Nathan R., Xie, Tianyou, Glover, S. E., Tolmachev, Sergei Y., Dong, Zhongyum, Spitz, Henry B.
Format: Article
Language:English
Subjects:
Alpha particles
Alpha rays
Autoradiography
Chemistry
Chemistry and Materials Science
Diagnostic Radiology
Dosage
Hadrons
Heavy Ions
Inorganic Chemistry
Ionization
Kidneys
Linear energy transfer (LET)
Liver
Microdosimeters
Nuclear Chemistry
Nuclear Physics
Nuclear Science & Technology
Particle deposition
Particle tracking
Physical Chemistry
Progeny
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Description
Summary:Targeted alpha therapy has the properties of direct ionization, oxygen independency, high linear energy transfer, a short half-life, and minimal depth of penetration, which are advantageous in cancer treatment. This modified, inexpensive, high-resolution, autoradiographic study of 232 Th decay in a tissue specimen, to both locate and quantify individual alpha-particle origins, track lengths, and dose rates, utilized conventional Ilford Pan F Plus, 135–36, Black and White, 35 mm, ISO 50 film. Dose rates measured 0.14 cGy d −1 in the liver, 0.03 cGy d −1 in the right kidney, and 0.003 cGy d −1 in the heart, leading to a dosimetric concern of where the final alpha-particle deposition occurs.
ISSN:0236-5731
1588-2780
DOI:10.1007/s10967-018-6049-0