Structures of EccB1 and EccD1 from the core complex of the mycobacterial ESX-1 type VII secretion system

The ESX-1 type VII secretion system is an important determinant of virulence in pathogenic mycobacteria, including Mycobacterium tuberculosis. This complicated molecular machine secretes folded proteins through the mycobacterial cell envelope to subvert the host immune response. Despite its importan...

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Bibliographic Details
Published in:BMC structural biology 2016-02, Vol.16 (1)
Main Authors: Wagner, Jonathan M., Chan, Sum, Evans, Timothy J., Kahng, Sara, Kim, Jennifer, Arbing, Mark A., Eisenberg, David, Korotkov, Konstantin V.
Format: Article
Language:English
Subjects:
60 APPLIED LIFE SCIENCES
BASIC BIOLOGICAL SCIENCES
EccB
EccD
ESX
Mycobacterium tuberculosis
Type VII secretion system
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Summary:The ESX-1 type VII secretion system is an important determinant of virulence in pathogenic mycobacteria, including Mycobacterium tuberculosis. This complicated molecular machine secretes folded proteins through the mycobacterial cell envelope to subvert the host immune response. Despite its important role in disease very little is known about the molecular architecture of the ESX-1 secretion system.
ISSN:1472-6807
1472-6807