Complex and extensive post-transcriptional regulation revealed by integrative proteomic and transcriptomic analysis of metabolite stress response in Clostridium acetobutylicum

Clostridium acetobutylicum is a model organism for both clostridial biology and solvent production. The organism is exposed to its own toxic metabolites butyrate and butanol, which trigger an adaptive stress response. Integrative analysis of proteomic and RNAseq data may provide novel insights into...

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Bibliographic Details
Published in:Biotechnology for biofuels 2015-06, Vol.8 (1)
Main Authors: Venkataramanan, Keerthi P., Min, Lie, Hou, Shuyu, Jones, Shawn W., Ralston, Matthew T., Lee, Kelvin H., Papoutsakis, E. Terry
Format: Article
Language:English
Subjects:
BASIC BIOLOGICAL SCIENCES
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Summary:Clostridium acetobutylicum is a model organism for both clostridial biology and solvent production. The organism is exposed to its own toxic metabolites butyrate and butanol, which trigger an adaptive stress response. Integrative analysis of proteomic and RNAseq data may provide novel insights into post-transcriptional regulation.
ISSN:1754-6834
1754-6834