Composite coatings of Mg-MOF74 and Sr-substituted hydroxyapatite on titanium substrates for local antibacterial, anti-osteosarcoma and pro-osteogenesis applications

Schematic diagram of potential mechanisms in anti-bacteria, anti-osteosarcoma and pro-osteogenesis of Sr-HA-MOF74 substrates. [Display omitted] •Composite coatings of Mg-MOF74 and Sr-HA were constructed on titanium substrates.•Mg-MOF74 is sensitive to acid condition caused by bacteria or Saos-2 cell...

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Bibliographic Details
Published in:Materials letters 2019-04, Vol.241 (C), p.18-22
Main Authors: Zhang, Yangyang, Shen, Xinkun, Ma, Pingping, Peng, Zhihong, Cai, Kaiyong
Format: Article
Language:English
Subjects:
Anti-osteosarcoma
Antibacterial
Bacteria
Biocompatibility
Biomaterials
Bone cancer
Differentiation (biology)
E coli
Hydroxyapatite
Magnesium
Materials science
Metal-organic frameworks
Mg-MOF74
Nanocomposites
Osteoblasts
Protective coatings
Strontium
Substitutes
Substrates
Surfaces
Surgical implants
Titanium
Transplants & implants
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Summary:Schematic diagram of potential mechanisms in anti-bacteria, anti-osteosarcoma and pro-osteogenesis of Sr-HA-MOF74 substrates. [Display omitted] •Composite coatings of Mg-MOF74 and Sr-HA were constructed on titanium substrates.•Mg-MOF74 is sensitive to acid condition caused by bacteria or Saos-2 cells.•Mg-MOF74 affords superior bacteria and osteosarcoma resistances to Sr-HA-MOF74.•Sr-HA-MOF74 greatly improves osteogenesis once surficial MOF74 coating degraded. It has been noticed that residual osteosarcoma cells or infective bacteria would greatly hinder the osseointegration between implants and natural bone at the early stage of implant surgeries. Thus, in this work, composite coatings of magnesium-mediated metal-organic frameworks (Mg-MOF74) and strontium-substituted hydroxyapatite (Sr-HA) were constructed on titanium surfaces for improving the local injury treatment even with complications (osteosarcoma or bacterial infection). It was proved that the superficial Mg-MOF74 could rapidly degrade (especially under bacteria- or osteosarcoma-induced acid microenvironment) and effectively kill surrounding Staphylococcus aureus, Escherichia coli and Saos-2 cells, and then the exposed Sr-HA coating had great potential to promote the proliferation and osteogenic differentiation of osteoblasts.
ISSN:0167-577X
1873-4979
DOI:10.1016/j.matlet.2019.01.033