Rats bred for helplessness exhibit positive reinforcement learning deficits which are not alleviated by an antidepressant dose of the MAO-B inhibitor deprenyl

Highlights • Studied positive reinforcement learning in a congenital rat model of depression. • Congenitally helpless (cH) rats were impaired in acquiring operant contingencies. • cH rats did not exhibit deficiencies in appetite or reward sensitivity. • MAO-B inhibitor deprenyl reduced immobility of...

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Bibliographic Details
Published in:Neuroscience 2016-08, Vol.329 (C), p.83-92
Main Authors: Schulz, Daniela, Henn, Fritz A, Petri, David, Huston, Joseph P
Format: Article
Language:English
Subjects:
animal model
Animals
antidepressant
Antidepressive Agents - pharmacology
Appetite
Conditioning, Operant - drug effects
depression
Depressive Disorder - drug therapy
Disease Models, Animal
Extinction, Psychological
Helplessness, Learned
learned helplessness
Learning Disorders - drug therapy
Male
Monoamine Oxidase Inhibitors - pharmacology
motivation
Motivation - drug effects
Motivation - physiology
Motor Activity - drug effects
Neurology
Nootropic Agents - pharmacology
operant learning
Rats, Sprague-Dawley
Reinforcement (Psychology)
Resilience, Psychological - drug effects
Selegiline - pharmacology
Species Specificity
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Summary:Highlights • Studied positive reinforcement learning in a congenital rat model of depression. • Congenitally helpless (cH) rats were impaired in acquiring operant contingencies. • cH rats did not exhibit deficiencies in appetite or reward sensitivity. • MAO-B inhibitor deprenyl reduced immobility of cH rats in the forced swim test. • Deprenyl did not reverse deficits of cH rats in positive reinforcement learning.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2016.04.049