Integration of a Multichannel Pulsed-Valve Inlet System to a Linear Quadrupole Ion Trap Mass Spectrometer for the Rapid Consecutive Introduction of Nine Reagents for Diagnostic Ion/Molecule Reactions

Gas-phase ion/molecule reactions have been used extensively for the structural elucidation of organic compounds in tandem mass spectrometry. Reagents for ion/molecule reactions can be introduced into a mass spectrometer via a continuous flow apparatus or through a pulsed inlet system. However, most...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 2019-12, Vol.91 (24), p.15652-15660
Main Authors: Kong, John Y, Hilger, Ryan T, Jin, Chunfen, Yerabolu, Ravikiran, Zimmerman, James R, Replogle, Randall W, Jarrell, Tiffany M, Easterling, Leah, Kumar, Rashmi, Kenttämaa, Hilkka I
Format: Article
Language:English
Subjects:
Analytical chemistry
Cascade chemical reactions
Chemistry
Continuous flow
Diagnostic systems
High performance liquid chromatography
High-throughput screening
Ions
Liquid chromatography
Mass spectrometry
Mass spectroscopy
Organic compounds
Quadrupoles
Reagents
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Summary:Gas-phase ion/molecule reactions have been used extensively for the structural elucidation of organic compounds in tandem mass spectrometry. Reagents for ion/molecule reactions can be introduced into a mass spectrometer via a continuous flow apparatus or through a pulsed inlet system. However, most of these approaches enable the use of only a single reagent at a time. In this work, a multichannel pulsed-valve inlet system was developed for the rapid consecutive introduction of up to nine different reagents or reagent systems into a linear quadrupole ion trap mass spectrometer for diagnostic gas-phase ion/molecule reactions. Automated triggering of the pulsed valves enabled these experiments to be performed on the high-performance liquid chromatography (HPLC) time scale. This enables high-throughput screening of several functionalities in analytes as they elute from an HPLC column.
ISSN:0003-2700
1520-6882
DOI:10.1021/acs.analchem.9b03768