Single-entity electrochemistry at confined sensing interfaces

Absract Measurements at the single-entity level provide more precise diagnosis and understanding of basic biological and chemical processes. Recent advances in the chemical measurement provide a means for ultra-sensitive analysis. Confining the single analyte and electrons near the sensing interface...

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Bibliographic Details
Published in:Science China. Chemistry 2020-05, Vol.63 (5), p.589-618
Main Authors: Ying, Yi-Lun, Wang, Jiajun, Leach, Anna Rose, Jiang, Ying, Gao, Rui, Xu, Cong, Edwards, Martin A., Pendergast, Andrew D., Ren, Hang, Weatherly, Connor K. Terry, Wang, Wei, Actis, Paolo, Mao, Lanqun, White, Henry S., Long, Yi-Tao
Format: Article
Language:English
Subjects:
Analytical chemistry
Biological activity
brain
Chemical reactions
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Confining
confining effect
Electrochemistry
INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Interfaces
Morphology
Nanomaterials
Nanoparticles
nanopores
Reviews
Science
Sensitivity enhancement
Sensors
single cell
single entity
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Summary:Absract Measurements at the single-entity level provide more precise diagnosis and understanding of basic biological and chemical processes. Recent advances in the chemical measurement provide a means for ultra-sensitive analysis. Confining the single analyte and electrons near the sensing interface can greatly enhance the sensitivity and selectivity. In this review, we summarize the recent progress in single-entity electrochemistry of single molecules, single particles, single cells and even brain analysis. The benefits of confining these entities to a compatible size sensing interface are exemplified. Finally, the opportunities and challenges of single entity electrochemistry are addressed.
ISSN:1674-7291
1869-1870
DOI:10.1007/s11426-020-9716-2