Leveraging Framework Instability: A Journey from Energy Storage to Drug Delivery

Abstract Amorphous pharmaceuticals often suffer from poor physical stability, which can negate their high solubility, fast dissolution rate, and better oral bioavailability vs. crystalline forms. This represents a major hurdle to processing, storage, and delivery of amorphous pharmaceuticals. Severa...

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Bibliographic Details
Published in:Synlett 2020-10, Vol.31 (16), p.1573-1580
Main Authors: Suresh, Kuthuru, López-Mejías, Vilmalí, Roy, Saikat, Camacho, Daniel F., Matzger, Adam J.
Format: Article
Language:English
Subjects:
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Chemistry
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Summary:Abstract Amorphous pharmaceuticals often suffer from poor physical stability, which can negate their high solubility, fast dissolution rate, and better oral bioavailability vs. crystalline forms. This represents a major hurdle to processing, storage, and delivery of amorphous pharmaceuticals. Several approaches to addressing these problems have been pursued, but there is still a need for a general method for stabilizing the amorphous form. We describe a novel approach using a water-unstable metal-organic framework as a drug delivery vehicle that demonstrates improved amorphous form stability accompanied by remarkably enhanced solubility and a fast dissolution rate. This research project spanned eleven years from conception to realization and dissemination. With origins in understanding the stability or porous solids for energy storage materials, the work also highlights potential of basic science understanding to illuminate new areas of application.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0040-1707139