A heavy-ion production channel of 149Tb via 63Cu bombardment of 89Y

The radionuclide 149Tb (t1/2 = 4.1 h) is a potential theranostic isotope which can simultaneously be used for targeted-alpha-particle therapy and positron-emission tomography. Feasibility experiments were performed to test a near-symmetric heavy-ion reaction of 63Cu bombardment on monoisotopic 89Y....

Full description

Saved in:
Bibliographic Details
Published in:Applied radiation and isotopes 2021-12, Vol.178 (C), p.109935-109935, Article 109935
Main Authors: Wilkinson, John T., Barrett, Kendall E., Ferran, Samuel J., McGuinness, Sean R., McIntosh, Lauren A., McCarthy, Mallory, Yennello, Sherry J., Engle, Jonathan W., Lapi, Suzanne E., Peaslee, Graham F.
Format: Article
Language:English
Subjects:
149Tb
Heavy-ions
INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Isotope production
NUCLEAR PHYSICS AND RADIATION PHYSICS
Theranostics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The radionuclide 149Tb (t1/2 = 4.1 h) is a potential theranostic isotope which can simultaneously be used for targeted-alpha-particle therapy and positron-emission tomography. Feasibility experiments were performed to test a near-symmetric heavy-ion reaction of 63Cu bombardment on monoisotopic 89Y. The indirect reaction was studied to avoid isomer production. Offline gamma spectroscopy was used to quantify thick-target physical yields and experimental results show modest agreement to the fusion-evaporation code PACE4. A near-symmetric fission yield was also observed. •Indirect heavy-ion reactions were investigated for the production of 149Tb.•Gamma spectroscopy was used to quantify thick-target physical yields.•PACE4 fusion-evaporation predictions show modest agreement to experimental results.•A near-symmetric fission yield was observed for the compound nucleus 152Er.
ISSN:0969-8043
1872-9800
DOI:10.1016/j.apradiso.2021.109935