Engineering stability, longevity, and miscibility of microtubule-based active fluids

Microtubule-based active matter provides insight into the self-organization of motile interacting constituents. In this work, we describe several formulations of microtubule-based 3D active isotropic fluids. Dynamics of these fluids is powered by three types of kinesin motors: a processive motor, a...

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Bibliographic Details
Published in:Soft matter 2022-01, Vol.18 (9)
Main Authors: Chandrakar, Pooja, Berezney, John, Lemma, Bezia, Hishamunda, Bernard, Berry, Angela, Wu, Kun-Ta, Subramanian, Radhika, Chung, Johnson, Needleman, Daniel, Gelles, Jeff, Dogic, Zvonimir
Format: Article
Language:English
Subjects:
Chemistry
MATERIALS SCIENCE
Physics
Polymer Science
Online Access:Get full text
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Summary:Microtubule-based active matter provides insight into the self-organization of motile interacting constituents. In this work, we describe several formulations of microtubule-based 3D active isotropic fluids. Dynamics of these fluids is powered by three types of kinesin motors: a processive motor, a non-processive motor, and a motor which is permanently linked to a microtubule backbone. Another modification uses a specific microtubule crosslinker to induce bundle formation instead of a non-specific polymer depletant. In comparison to the already established system, each formulation exhibits distinct properties. These developments reveal the temporal stability of microtubule-based active fluids while extending their reach and the applicability.
ISSN:1744-683X
1744-6848