Effects of Great Lakes Fish Consumption on Brain PCB Pattern, Concentration, and Progressive-Ratio Performance

This study investigated the effects of consumption of Great Lakes fish on progressive ratio performance, and on the pattern and concentrations of brain polychlorinated biphenyls (PCBs), dichlorodiphenyldichloroethene (DDE), and mirex in the rat. Adult, male Sprague–Dawley rats were fed a 30% diet of...

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Bibliographic Details
Published in:Environmental research 2000-01, Vol.82 (1), p.18-32
Main Authors: Stewart, Paul, Pagano, James, Sargent, David, Darvill, Thomas, Lonky, Edward, Reihman, Jacqueline
Format: Article
Language:English
Subjects:
Adult
Animals
Biological and medical sciences
BIOLOGICAL INDICATORS
BIOLOGICAL MODELS
Body Weight
BRAIN
Brain - metabolism
CHLORINATED ALIPHATIC HYDROCARBONS
Dichlorodiphenyl Dichloroethylene - pharmacokinetics
dichlorodiphenyldichloroethene
Environmental Pollutants - pharmacokinetics
ENVIRONMENTAL SCIENCES
FOOD CHAINS
Food toxicology
Great Lakes fish
Great Lakes Region
Humans
Insecticides - pharmacokinetics
LAKE ONTARIO
Male
Medical sciences
mirex
Mirex - pharmacokinetics
Oncorhynchus kisutch - metabolism
POLYCHLORINATED BIPHENYLS
Polychlorinated Biphenyls - pharmacokinetics
RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS
Rats
Rats, Sprague-Dawley
SALMON
TOXICITY
Toxicology
WATER POLLUTION
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Summary:This study investigated the effects of consumption of Great Lakes fish on progressive ratio performance, and on the pattern and concentrations of brain polychlorinated biphenyls (PCBs), dichlorodiphenyldichloroethene (DDE), and mirex in the rat. Adult, male Sprague–Dawley rats were fed a 30% diet of either Lake Ontario salmon (LAKE), Pacific Ocean salmon, or lab chow control for 20 or 65 days. Following the treatment regimen, half the rats from each group were sacrificed immediately for gas chromatographic analysis of organochlorine contaminants, and the other half were tested on a multiple fixed-ratio–progressive–ratio reinforcement schedule and then sacrificed for analysis. Consumption of Lake Ontario fish resulted in significantly higher levels of brain PCBs, DDE, and mirex relative to controls, but still well within human exposure ranges (
ISSN:0013-9351
1096-0953
DOI:10.1006/enrs.1999.4005