A novel peptide sansalvamide analogue inhibits pancreatic cancer cell growth through G0/G1 cell-cycle arrest

Patients with pancreatic cancer have little hope for cure because no effective therapies are available. Sansalvamide A is a cyclic depsipeptide produced by a marine fungus. We investigated the effect of a novel sansalvamide A analogue on growth, cell-cycle phases, and induction of apoptosis in human...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2006-02, Vol.340 (4), p.1224-1228
Main Authors: Ujiki, Michael B., Milam, Ben, Ding, Xian-Zhong, Roginsky, Alexandra B., Salabat, M. Reza, Talamonti, Mark S., Bell, Richard H., Gu, Wenxin, Silverman, Richard B., Adrian, Thomas E.
Format: Article
Language:English
Subjects:
60 APPLIED LIFE SCIENCES
Annexin V
Antineoplastic Agents - administration & dosage
APOPTOSIS
CELL CYCLE
Cell Cycle - drug effects
Cell Line
CELL PROLIFERATION
Cell Proliferation - drug effects
Cell Survival - drug effects
Cell-cycle arrest
Depsipeptides - administration & dosage
DNA
Dose-Response Relationship, Drug
FUNGI
Humans
IN VITRO
INHIBITION
MORPHOLOGICAL CHANGES
NEOPLASMS
PANCREAS
Pancreatic cancer
Pancreatic Neoplasms - pathology
PATIENTS
PEPTIDES
Sansalvamide A
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Summary:Patients with pancreatic cancer have little hope for cure because no effective therapies are available. Sansalvamide A is a cyclic depsipeptide produced by a marine fungus. We investigated the effect of a novel sansalvamide A analogue on growth, cell-cycle phases, and induction of apoptosis in human pancreatic cancer cells in vitro. The sansalvamide analogue caused marked time- and concentration-dependent inhibition of DNA synthesis and cell proliferation of two human pancreatic cancer cell lines (AsPC-1 and S2-013). The analogue induced G0/G1 phase cell-cycle arrest and morphological changes suggesting induction of apoptosis. Apoptosis was confirmed by annexin V binding. This novel sansalvamide analogue inhibits growth of pancreatic cancer cells through G0/G1 arrest and induces apoptosis. Sansalvamide analogues may be valuable for the treatment of pancreatic cancer.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2005.12.131