Optimization of Beam-Shaping Assemblies for BNCS Using the High-Energy Neutron Sources D-D and D-T

Boron neutron capture synovectomy is a novel approach for the treatment of rheumatoid arthritis. The goal of the treatment is the ablation of diseased synovial membranes in articulating joints. The treatment of knee joints is the focus of this work. A method was developed, as discussed previously, t...

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Bibliographic Details
Published in:Nuclear technology 2001-06, Vol.134 (3), p.278-293
Main Authors: Verbeke, Jérôme M., Chen, Allen S., Vujic, Jasmina L., Leung, Ka-Ngo
Format: Article
Language:English
Subjects:
BEAM SHAPING
Biological and medical sciences
Biological membranes
BORON
BORON 10
CAPTURE
DEUTERIUM
Diseases
Diseases of the osteoarticular system. Orthopedic treatment
Joints (anatomy)
Medical sciences
NEUTRON BEAMS
NEUTRON REACTIONS
NEUTRON SOURCES
NEUTRONS
OPTIMIZATION
PARTICLE ACCELERATORS
PATIENTS
PHOTON BEAMS
RADIATION DOSE DISTRIBUTIONS
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
RHEUMATIC DISEASES
TRITIUM
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Summary:Boron neutron capture synovectomy is a novel approach for the treatment of rheumatoid arthritis. The goal of the treatment is the ablation of diseased synovial membranes in articulating joints. The treatment of knee joints is the focus of this work. A method was developed, as discussed previously, to predict the dose distribution in a knee joint from any neutron and photon beam spectra incident on the knee. This method is validated and used to design moderators for the deuterium-deuterium (D-D) and deuterium-tritium (D-T) neutron sources. Treatment times >2 h were obtained with the D-D reaction. They could potentially be reduced if the 10 B concentration in the synovium was increased. For D-T neutrons, high therapeutic ratios and treatment times
ISSN:0029-5450
1943-7471
DOI:10.13182/NT01-A3201