Decreased expression of thyroid receptor-associated protein 220 in temporal lobe tissue of patients with refractory epilepsy

TRAP220 (thyroid hormone receptor-associated protein) functions as a coactivator for nuclear receptors and stimulates transcription by recruiting the TRAP mediator complex to hormone responsive promoter regions. Thus, TRAP220 enhances the function of thyroid/steroid hormone receptors such as thyroid...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2006-10, Vol.348 (4), p.1389-1397
Main Authors: Li, Jin-mei, Wang, Xue-feng, Xi, Zhi-qin, Gong, Yun, Liu, Feng-ying, Sun, Ji-jun, Wu, Yuan, Luan, Guo-ming, Wang, Yu-ping, Li, Yun-lin, Zhang, Jian-guo, Lu, Yong, Li, Hong-wei
Format: Article
Language:English
Subjects:
60 APPLIED LIFE SCIENCES
Adolescent
Adult
Blotting, Western
BRAIN
Child
Down-Regulation
EPILEPSY
Epilepsy - diagnosis
Epilepsy - genetics
Epilepsy - metabolism
Female
Humans
Immunohistochemistry
Male
Mediator Complex Subunit 1
Middle Aged
PATIENTS
PROMOTERS
RECEPTORS
Refractory epilepsy
RNA, Messenger - metabolism
STEROID HORMONES
SURGERY
Temporal Lobe - metabolism
THYROID
THYROID HORMONES
Thyroid/steroid hormone receptors
TRANSCRIPTION
Transcription Factors - genetics
Transcription Factors - metabolism
TRAP220
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Summary:TRAP220 (thyroid hormone receptor-associated protein) functions as a coactivator for nuclear receptors and stimulates transcription by recruiting the TRAP mediator complex to hormone responsive promoter regions. Thus, TRAP220 enhances the function of thyroid/steroid hormone receptors such as thyroid hormone and oestrogen receptors. This study investigated the expression of TRAP220 mRNA and protein level in epileptic brains comparing with human control. We examined the expression of TRAP220 mRNA and protein levels in temporal lobes from patients with chronic pharmacoresistant epilepsy who have undergone surgery. Expression of TRAP220 mRNA and protein was shown to be decreased significantly in the temporal cortex of the patients with epilepsy. Our work showed that a decrease in TRAP220 mRNA and protein levels may be involved in the pathophysiology of epilepsy and may be associated with impairment of the brain caused by frequent seizures.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2006.08.010