Promotion of atherogenesis by copper or iron—Which is more likely?

Iron levels increase in atherosclerotic lesions in cholesterol fed-rabbits and play a role in atherosclerosis. We investigated whether copper also rises. Male New Zealand White rabbits were fed high-cholesterol diets for 8 weeks. After sacrifice, lesion sizes were determined, and elemental analyses...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2007-02, Vol.353 (1), p.6-10
Main Authors: Rajendran, Reshmi, Ren, Minqin, Ning, Pan, Tan Kwong Huat, Benny, Halliwell, Barry, Watt, Frank
Format: Article
Language:English
Subjects:
60 APPLIED LIFE SCIENCES
Animals
Aorta, Thoracic - metabolism
Aorta, Thoracic - pathology
Aortic Diseases - etiology
Aortic Diseases - metabolism
Aortic Diseases - pathology
ARTERIES
ARTERIOSCLEROSIS
Atherosclerosis - etiology
Atherosclerosis - metabolism
Atherosclerosis - pathology
CHOLESTEROL
Cholesterol, Dietary - adverse effects
COPPER
Copper - metabolism
Elemental analysis
IRON
Iron - metabolism
Male
MICROSCOPY
Nuclear microscopy
RABBITS
Tissue Distribution
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Summary:Iron levels increase in atherosclerotic lesions in cholesterol fed-rabbits and play a role in atherosclerosis. We investigated whether copper also rises. Male New Zealand White rabbits were fed high-cholesterol diets for 8 weeks. After sacrifice, lesion sizes were determined, and elemental analyses of the lesion and unaffected artery wall performed using nuclear microscopy. Unlike iron, lesion copper is decreased by about half compared with the unaffected artery wall, and much less copper than iron is present. Our data suggest that iron may be more likely to play a role in the promotion of atherosclerosis than copper.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2006.11.038