Proteins that associate with lamins: Many faces, many functions

Lamin-associated polypeptides (LAPs) comprise inner nuclear membrane proteins tightly associated with the peripheral lamin scaffold as well as proteins forming stable complexes with lamins in the nucleoplasm. The involvement of LAPs in a wide range of human diseases may be linked to an equally bewil...

Full description

Saved in:
Bibliographic Details
Published in:Experimental cell research 2007-06, Vol.313 (10), p.2167-2179
Main Authors: Schirmer, Eric C., Foisner, Roland
Format: Article
Language:English
Subjects:
60 APPLIED LIFE SCIENCES
Active Transport, Cell Nucleus - physiology
Animals
Cell Nucleus - genetics
Cell Nucleus - metabolism
Cell Nucleus - ultrastructure
Cellular biology
Chromatin
ENDOPLASMIC RETICULUM
FLUORESCENCE
Gene expression
Genetic Predisposition to Disease - genetics
GERM CELLS
GROWTH FACTORS
HETEROCHROMATIN
Humans
Lamin
Lamins - genetics
Lamins - metabolism
Macromolecular Substances - metabolism
Molecular biology
Nuclear envelope
Nuclear Envelope - genetics
Nuclear Envelope - metabolism
Nuclear Envelope - ultrastructure
Nuclear Proteins - genetics
Nuclear Proteins - metabolism
Nuclear Proteins - ultrastructure
Nuclear structure
Peptides - genetics
Peptides - metabolism
POLYPEPTIDES
Proteins
RECEPTORS
Signal Transduction - physiology
SKELETON
STEROLS
SUN
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Lamin-associated polypeptides (LAPs) comprise inner nuclear membrane proteins tightly associated with the peripheral lamin scaffold as well as proteins forming stable complexes with lamins in the nucleoplasm. The involvement of LAPs in a wide range of human diseases may be linked to an equally bewildering range of their functions, including sterol reduction, histone modification, transcriptional repression, and Smad- and β-catenin signaling. Many LAPs are likely to be at the center of large multi-protein complexes, components of which may dictate their functions, and a few LAPs have defined enzymatic activities. Here we discuss the definition of LAPs, review their many binding partners, elaborate their functions in nuclear architecture, chromatin organization, gene expression and signaling, and describe what is currently known about their links to human disease.
ISSN:0014-4827
1090-2422
DOI:10.1016/j.yexcr.2007.03.012