Association of tibia lead and blood lead with end-stage renal disease: A pilot study of African–Americans

The association between body lead burden and kidney disease remains controversial. Fifty-five African–American end-stage renal disease (ESRD) cases and 53 age- and sex-matched African–American controls without known renal disease were recruited from Tulane University-affiliated dialysis clinics and...

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Bibliographic Details
Published in:Environmental research 2007-07, Vol.104 (3), p.396-401
Main Authors: Muntner, Paul, Menke, Andy, Batuman, Vecihi, Rabito, Felicia A., He, Jiang, Todd, Andrew C.
Format: Article
Language:English
Subjects:
60 APPLIED LIFE SCIENCES
ABSORPTION SPECTROSCOPY
African Americans
Biological and medical sciences
BLOOD
Body lead burden
CADMIUM 109
Chemical and industrial products toxicology. Toxic occupational diseases
Chronic kidney disease
DIALYSIS
End-stage renal disease
Environmental Pollutants - analysis
Environmental Pollutants - blood
Environmental Pollutants - pharmacokinetics
Environmental Pollutants - toxicity
Female
FLUORESCENCE
Humans
K SHELL
Kidney Failure, Chronic - blood
Kidney Failure, Chronic - ethnology
Kidney Failure, Chronic - etiology
KIDNEYS
LEAD
Lead - analysis
Lead - blood
Lead - pharmacokinetics
Lead - toxicity
Male
Medical sciences
Metals and various inorganic compounds
Middle Aged
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Pilot Projects
Radiography
Renal failure
Spectrometry, X-Ray Emission
TIBIA
Tibia - diagnostic imaging
Tibia - metabolism
Toxicology
Urinary system involvement in other diseases. Miscellaneous
UROGENITAL SYSTEM DISEASES
X RADIATION
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Summary:The association between body lead burden and kidney disease remains controversial. Fifty-five African–American end-stage renal disease (ESRD) cases and 53 age- and sex-matched African–American controls without known renal disease were recruited from Tulane University-affiliated dialysis clinics and out-patient clinics, respectively. Blood lead was measured via atomic absorption spectrophotometry and tibia lead (a measure of body lead) was measured via 109Cd-based K shell X-ray fluorescence. Median blood lead levels were significantly higher among ESRD cases (6 μg/dL) compared to their control counterparts (3 μg/dL; P
ISSN:0013-9351
1096-0953
DOI:10.1016/j.envres.2007.04.001