Reproductive toxicity of low-level lead exposure in men

• Published in: Environmental research 2007-10, Vol.105 (2), p.256-266
• Main Authors: Telišman, Spomenka, Čolak, Božo, Pizent, Alica, Jurasović, Jasna, Cvitković, Petar
• Format: Article
• Language: English
• Subjects: 60 APPLIED LIFE SCIENCES; Adult; ALCOHOLS; AMINOLEVULINIC ACID; Biological and medical sciences; BIOLOGICAL MARKERS; BODY BURDEN; CADMIUM; Chemical and industrial products toxicology. Toxic occupational diseases; COPPER; Croatia - epidemiology; Environmental Exposure - adverse effects; Environmental Pollutants - blood; Environmental Pollutants - toxicity; ERYTHROCYTES; ESTRADIOL; Estradiol - blood; Human semen quality; Humans; LEAD; LTH; Male; Medical sciences; MEN; Metals and various inorganic compounds; Metals, Heavy - blood; Metals, Heavy - toxicity; Middle Aged; NEOPLASMS; Nonoccupational lead exposure; OCCUPATIONAL EXPOSURE; Porphobilinogen Synthase - blood; Prolactin - blood; PROSTATE; Prostate damage; Protoporphyrins - blood; Reproduction - drug effects; SELENIUM; Sex hormones; SPERMATOZOA; Spermatozoa - growth & development; Spermatozoa - pathology; SULFUR 49; TESTOSTERONE; Testosterone - blood; Toxic and essential metals interaction; TOXICITY; Toxicology; ZINC
• ISSN: 0013-9351; 1096-0953
• DOI: 10.1016/j.envres.2007.05.011

Parameters of semen quality, seminal plasma indicators of secretory function of the prostate and seminal vesicles, sex hormones in serum, and biomarkers of lead, cadmium, copper, zinc, and selenium body burden were measured in 240 Croatian men 19–52 years of age. The subjects had no occupational exposure to metals and no known other reasons suspected of influencing male reproductive function or metal metabolism. After adjusting for age, smoking, alcohol, blood cadmium, and serum copper, zinc, and selenium by multiple regression, significant ( P