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Intraarterial infusion therapy via a subcutaneous port for limb-threatening ischemia : A pilot study
To present the initial results of a new percutaneously implantable catheter port system (PIPS) used for long-term intraarterial infusion therapy in patients with severe ischemic limb disease. Ten patients with deep, extended ischemic ulcerations (all 10) and osteomyelitis (6/10) of the foot received...
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| Published in: | Cardiovascular and interventional radiology 1998-03, Vol.21 (2), p.109-115 |
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| Main Authors: | , , |
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| Language: | English |
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| container_end_page | 115 |
| container_issue | 2 |
| container_start_page | 109 |
| container_title | Cardiovascular and interventional radiology |
| container_volume | 21 |
| creator | STRECKER, E.-P. K OSTHEIM-DZEROWYCZ, W BOOS, I. B. L |
| description | To present the initial results of a new percutaneously implantable catheter port system (PIPS) used for long-term intraarterial infusion therapy in patients with severe ischemic limb disease.
Ten patients with deep, extended ischemic ulcerations (all 10) and osteomyelitis (6/10) of the foot received intraarterial infusions of prostaglandine E1 and antibiotics, if indicated, via a new port catheter system with the port placed subcutaneously above the groin after percutaneous introduction and the catheter tip placed into the superficial or deep femoral artery.
Port implantation and repeated port access were uncomplicated. During the follow-up period (mean 11 months, range 1 week-50 months), port migration, leakage, or infection was not observed. Three catheters thrombosed and were opened by fibrinolysis with recombinant tissue plasminogen activator instilled via the port. Treatment success was achieved in 8 patients: relief from rest pain (8 patients), reduction of ulcer size (4/8), and complete healing (4/8). Limb savage rate was 80%. In 2 patients amputation could not be avoided.
Selective long-term arterial infusion therapy presents a valuable therapeutic regimen for limb salvage. With the new catheter port system, repeated local intraarterial infusion is safe and simple. |
| doi_str_mv | 10.1007/s002709900225 |
| format | article |
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Ten patients with deep, extended ischemic ulcerations (all 10) and osteomyelitis (6/10) of the foot received intraarterial infusions of prostaglandine E1 and antibiotics, if indicated, via a new port catheter system with the port placed subcutaneously above the groin after percutaneous introduction and the catheter tip placed into the superficial or deep femoral artery.
Port implantation and repeated port access were uncomplicated. During the follow-up period (mean 11 months, range 1 week-50 months), port migration, leakage, or infection was not observed. Three catheters thrombosed and were opened by fibrinolysis with recombinant tissue plasminogen activator instilled via the port. Treatment success was achieved in 8 patients: relief from rest pain (8 patients), reduction of ulcer size (4/8), and complete healing (4/8). Limb savage rate was 80%. In 2 patients amputation could not be avoided.
Selective long-term arterial infusion therapy presents a valuable therapeutic regimen for limb salvage. With the new catheter port system, repeated local intraarterial infusion is safe and simple.</description><identifier>ISSN: 0174-1551</identifier><identifier>EISSN: 1432-086X</identifier><identifier>DOI: 10.1007/s002709900225</identifier><identifier>PMID: 9502676</identifier><identifier>CODEN: CAIRDG</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Alprostadil - administration & dosage ; ANTIBIOTICS ; ARTERIES ; Biological and medical sciences ; Catheters, Indwelling - adverse effects ; Diseases of the cardiovascular system ; FEET ; Female ; Femoral Artery ; FIBRINOLYSIS ; Foot - blood supply ; HEALING ; Humans ; INFUSION ; Infusions, Intra-Arterial - adverse effects ; Infusions, Intra-Arterial - instrumentation ; Infusions, Intra-Arterial - methods ; ISCHEMIA ; Ischemia - drug therapy ; Leg - blood supply ; Male ; Medical sciences ; Middle Aged ; OSTEOMYELITIS ; PAIN ; PATIENTS ; Pilot Projects ; PLASMINOGEN ; RADIOLOGY AND NUCLEAR MEDICINE ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; THERAPY ; ULCERS ; Vasodilator Agents - administration & dosage</subject><ispartof>Cardiovascular and interventional radiology, 1998-03, Vol.21 (2), p.109-115</ispartof><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c345t-b73dd68a06a0139974196b1b6c07c213bea029ec76fe545bc2c0a987b37317af3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2207941$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9502676$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/21080418$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>STRECKER, E.-P. K</creatorcontrib><creatorcontrib>OSTHEIM-DZEROWYCZ, W</creatorcontrib><creatorcontrib>BOOS, I. B. L</creatorcontrib><title>Intraarterial infusion therapy via a subcutaneous port for limb-threatening ischemia : A pilot study</title><title>Cardiovascular and interventional radiology</title><addtitle>Cardiovasc Intervent Radiol</addtitle><description>To present the initial results of a new percutaneously implantable catheter port system (PIPS) used for long-term intraarterial infusion therapy in patients with severe ischemic limb disease.
Ten patients with deep, extended ischemic ulcerations (all 10) and osteomyelitis (6/10) of the foot received intraarterial infusions of prostaglandine E1 and antibiotics, if indicated, via a new port catheter system with the port placed subcutaneously above the groin after percutaneous introduction and the catheter tip placed into the superficial or deep femoral artery.
Port implantation and repeated port access were uncomplicated. During the follow-up period (mean 11 months, range 1 week-50 months), port migration, leakage, or infection was not observed. Three catheters thrombosed and were opened by fibrinolysis with recombinant tissue plasminogen activator instilled via the port. Treatment success was achieved in 8 patients: relief from rest pain (8 patients), reduction of ulcer size (4/8), and complete healing (4/8). Limb savage rate was 80%. In 2 patients amputation could not be avoided.
Selective long-term arterial infusion therapy presents a valuable therapeutic regimen for limb salvage. With the new catheter port system, repeated local intraarterial infusion is safe and simple.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alprostadil - administration & dosage</subject><subject>ANTIBIOTICS</subject><subject>ARTERIES</subject><subject>Biological and medical sciences</subject><subject>Catheters, Indwelling - adverse effects</subject><subject>Diseases of the cardiovascular system</subject><subject>FEET</subject><subject>Female</subject><subject>Femoral Artery</subject><subject>FIBRINOLYSIS</subject><subject>Foot - blood supply</subject><subject>HEALING</subject><subject>Humans</subject><subject>INFUSION</subject><subject>Infusions, Intra-Arterial - adverse effects</subject><subject>Infusions, Intra-Arterial - instrumentation</subject><subject>Infusions, Intra-Arterial - methods</subject><subject>ISCHEMIA</subject><subject>Ischemia - drug therapy</subject><subject>Leg - blood supply</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>OSTEOMYELITIS</subject><subject>PAIN</subject><subject>PATIENTS</subject><subject>Pilot Projects</subject><subject>PLASMINOGEN</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>THERAPY</subject><subject>ULCERS</subject><subject>Vasodilator Agents - administration & dosage</subject><issn>0174-1551</issn><issn>1432-086X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNpV0EtLxDAUBeAgio6PpUshoNvqTdI0jTsRHwOCGwV35SZNnUgnLUkqzL-3MoPg6izOd-_iEHLO4JoBqJsEwBVoPQeXe2TBSsELqKuPfbIApsqCScmOyHFKXwBM1lwekkMtgVeqWpB2GXJEjNlFjz31oZuSHwLNKxdx3NBvjxRpmoydMgY3TImOQ8y0GyLt_doUeRUdZhd8-KQ-2ZVbzxe39I6Ovh8yTXlqN6fkoMM-ubNdnpD3x4e3--fi5fVpeX_3UlhRylwYJdq2qhEqBCa0ViXTlWGmsqAsZ8I4BK6dVVXnZCmN5RZQ18oIJZjCTpyQy-3fIWXfJOuzsys7hOBsbjiDGkpWz6rYKhuHlKLrmjH6NcZNw6D5nbT5N-nsL7Z-nMzatX96t-HcX-16TBb7LmKwPv0xzkHpkokfMNp9_g</recordid><startdate>19980301</startdate><enddate>19980301</enddate><creator>STRECKER, E.-P. K</creator><creator>OSTHEIM-DZEROWYCZ, W</creator><creator>BOOS, I. B. L</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>OTOTI</scope></search><sort><creationdate>19980301</creationdate><title>Intraarterial infusion therapy via a subcutaneous port for limb-threatening ischemia : A pilot study</title><author>STRECKER, E.-P. K ; OSTHEIM-DZEROWYCZ, W ; BOOS, I. B. L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c345t-b73dd68a06a0139974196b1b6c07c213bea029ec76fe545bc2c0a987b37317af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alprostadil - administration & dosage</topic><topic>ANTIBIOTICS</topic><topic>ARTERIES</topic><topic>Biological and medical sciences</topic><topic>Catheters, Indwelling - adverse effects</topic><topic>Diseases of the cardiovascular system</topic><topic>FEET</topic><topic>Female</topic><topic>Femoral Artery</topic><topic>FIBRINOLYSIS</topic><topic>Foot - blood supply</topic><topic>HEALING</topic><topic>Humans</topic><topic>INFUSION</topic><topic>Infusions, Intra-Arterial - adverse effects</topic><topic>Infusions, Intra-Arterial - instrumentation</topic><topic>Infusions, Intra-Arterial - methods</topic><topic>ISCHEMIA</topic><topic>Ischemia - drug therapy</topic><topic>Leg - blood supply</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>OSTEOMYELITIS</topic><topic>PAIN</topic><topic>PATIENTS</topic><topic>Pilot Projects</topic><topic>PLASMINOGEN</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>THERAPY</topic><topic>ULCERS</topic><topic>Vasodilator Agents - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>STRECKER, E.-P. K</creatorcontrib><creatorcontrib>OSTHEIM-DZEROWYCZ, W</creatorcontrib><creatorcontrib>BOOS, I. B. L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>OSTI.GOV</collection><jtitle>Cardiovascular and interventional radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>STRECKER, E.-P. K</au><au>OSTHEIM-DZEROWYCZ, W</au><au>BOOS, I. B. L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intraarterial infusion therapy via a subcutaneous port for limb-threatening ischemia : A pilot study</atitle><jtitle>Cardiovascular and interventional radiology</jtitle><addtitle>Cardiovasc Intervent Radiol</addtitle><date>1998-03-01</date><risdate>1998</risdate><volume>21</volume><issue>2</issue><spage>109</spage><epage>115</epage><pages>109-115</pages><issn>0174-1551</issn><eissn>1432-086X</eissn><coden>CAIRDG</coden><abstract>To present the initial results of a new percutaneously implantable catheter port system (PIPS) used for long-term intraarterial infusion therapy in patients with severe ischemic limb disease.
Ten patients with deep, extended ischemic ulcerations (all 10) and osteomyelitis (6/10) of the foot received intraarterial infusions of prostaglandine E1 and antibiotics, if indicated, via a new port catheter system with the port placed subcutaneously above the groin after percutaneous introduction and the catheter tip placed into the superficial or deep femoral artery.
Port implantation and repeated port access were uncomplicated. During the follow-up period (mean 11 months, range 1 week-50 months), port migration, leakage, or infection was not observed. Three catheters thrombosed and were opened by fibrinolysis with recombinant tissue plasminogen activator instilled via the port. Treatment success was achieved in 8 patients: relief from rest pain (8 patients), reduction of ulcer size (4/8), and complete healing (4/8). Limb savage rate was 80%. In 2 patients amputation could not be avoided.
Selective long-term arterial infusion therapy presents a valuable therapeutic regimen for limb salvage. With the new catheter port system, repeated local intraarterial infusion is safe and simple.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>9502676</pmid><doi>10.1007/s002709900225</doi><tpages>7</tpages></addata></record> |
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| ispartof | Cardiovascular and interventional radiology, 1998-03, Vol.21 (2), p.109-115 |
| issn | 0174-1551 1432-086X |
| language | eng |
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| source | Springer Link |
| subjects | Adult Aged Aged, 80 and over Alprostadil - administration & dosage ANTIBIOTICS ARTERIES Biological and medical sciences Catheters, Indwelling - adverse effects Diseases of the cardiovascular system FEET Female Femoral Artery FIBRINOLYSIS Foot - blood supply HEALING Humans INFUSION Infusions, Intra-Arterial - adverse effects Infusions, Intra-Arterial - instrumentation Infusions, Intra-Arterial - methods ISCHEMIA Ischemia - drug therapy Leg - blood supply Male Medical sciences Middle Aged OSTEOMYELITIS PAIN PATIENTS Pilot Projects PLASMINOGEN RADIOLOGY AND NUCLEAR MEDICINE Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) THERAPY ULCERS Vasodilator Agents - administration & dosage |
| title | Intraarterial infusion therapy via a subcutaneous port for limb-threatening ischemia : A pilot study |
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