Endovascular stents and stent-grafts : Is heparin coating desirable?

Heparins are glycosaminoglycans that, in addition to their anticoagulant activity, have interactions with growth factors and other glycoproteins. These interactions may stimulate neointimal hyperplasia when heparin is delivered locally on stents and stent-grafts. Modifying the structure of heparin t...

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Bibliographic Details
Published in:Cardiovascular and interventional radiology 2000-07, Vol.23 (4), p.252-255
Main Authors: NELSON, Stephen R, DESOUZA, Nandita M, ALLISON, David J
Format: Article
Language:English
Subjects:
Animals
Anticoagulants - chemistry
Anticoagulants - pharmacology
Arterial Occlusive Diseases - surgery
Biological and medical sciences
Blood Vessel Prosthesis Implantation - instrumentation
Cell Division - drug effects
Coated Materials, Biocompatible
Diseases of the cardiovascular system
ENDOTHELIUM
Endothelium, Vascular - drug effects
Endothelium, Vascular - pathology
Fibroblast Growth Factors - drug effects
Fibroblast Growth Factors - metabolism
GLYCOPROTEINS
Graft Occlusion, Vascular - metabolism
Graft Occlusion, Vascular - pathology
Graft Occlusion, Vascular - prevention & control
Graft Survival
GRAFTS
GROWTH FACTORS
HEPARIN
Heparin - chemistry
Heparin - pharmacology
Humans
Medical sciences
Molecular Structure
MOLECULES
Polyethylene Terephthalates
Prosthesis Design
RADIOLOGY AND NUCLEAR MEDICINE
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Stents
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Description
Summary:Heparins are glycosaminoglycans that, in addition to their anticoagulant activity, have interactions with growth factors and other glycoproteins. These interactions may stimulate neointimal hyperplasia when heparin is delivered locally on stents and stent-grafts. Modifying the structure of heparin to retain anticoagulant activity while minimizing these stimulatory effects on the vascular endothelium is desirable and may be achieved by understanding the relationships between the structure and function of the various parts of the heparin molecule.
ISSN:0174-1551
1432-086X
DOI:10.1007/s002700010064