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Endovascular stents and stent-grafts : Is heparin coating desirable?

Heparins are glycosaminoglycans that, in addition to their anticoagulant activity, have interactions with growth factors and other glycoproteins. These interactions may stimulate neointimal hyperplasia when heparin is delivered locally on stents and stent-grafts. Modifying the structure of heparin t...

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Published in:	Cardiovascular and interventional radiology 2000-07, Vol.23 (4), p.252-255
Main Authors:	NELSON, Stephen R, DESOUZA, Nandita M, ALLISON, David J
Format:	Article
Language:	English
Subjects:	Animals Anticoagulants - chemistry Anticoagulants - pharmacology Arterial Occlusive Diseases - surgery Biological and medical sciences Blood Vessel Prosthesis Implantation - instrumentation Cell Division - drug effects Coated Materials, Biocompatible Diseases of the cardiovascular system ENDOTHELIUM Endothelium, Vascular - drug effects Endothelium, Vascular - pathology Fibroblast Growth Factors - drug effects Fibroblast Growth Factors - metabolism GLYCOPROTEINS Graft Occlusion, Vascular - metabolism Graft Occlusion, Vascular - pathology Graft Occlusion, Vascular - prevention & control Graft Survival GRAFTS GROWTH FACTORS HEPARIN Heparin - chemistry Heparin - pharmacology Humans Medical sciences Molecular Structure MOLECULES Polyethylene Terephthalates Prosthesis Design RADIOLOGY AND NUCLEAR MEDICINE Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Stents
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cited_by	cdi_FETCH-LOGICAL-c373t-a6baee3cd14d8cfae8389432191d8eb9d60b38a1fa6506fc08bde2cfcf0f1e7b3
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container_title	Cardiovascular and interventional radiology
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creator	NELSON, Stephen R DESOUZA, Nandita M ALLISON, David J
description	Heparins are glycosaminoglycans that, in addition to their anticoagulant activity, have interactions with growth factors and other glycoproteins. These interactions may stimulate neointimal hyperplasia when heparin is delivered locally on stents and stent-grafts. Modifying the structure of heparin to retain anticoagulant activity while minimizing these stimulatory effects on the vascular endothelium is desirable and may be achieved by understanding the relationships between the structure and function of the various parts of the heparin molecule.
doi_str_mv	10.1007/s002700010064
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subjects	Animals Anticoagulants - chemistry Anticoagulants - pharmacology Arterial Occlusive Diseases - surgery Biological and medical sciences Blood Vessel Prosthesis Implantation - instrumentation Cell Division - drug effects Coated Materials, Biocompatible Diseases of the cardiovascular system ENDOTHELIUM Endothelium, Vascular - drug effects Endothelium, Vascular - pathology Fibroblast Growth Factors - drug effects Fibroblast Growth Factors - metabolism GLYCOPROTEINS Graft Occlusion, Vascular - metabolism Graft Occlusion, Vascular - pathology Graft Occlusion, Vascular - prevention & control Graft Survival GRAFTS GROWTH FACTORS HEPARIN Heparin - chemistry Heparin - pharmacology Humans Medical sciences Molecular Structure MOLECULES Polyethylene Terephthalates Prosthesis Design RADIOLOGY AND NUCLEAR MEDICINE Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Stents
title	Endovascular stents and stent-grafts : Is heparin coating desirable?
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