Micro-CT of carotid arteries: a tool for experimental studies

Micro-computed tomography (micro-CT) is a high-resolution, non-destructive tool for two- and three-dimensional imaging and quantification. The ability of this technique to assess atherosclerosis of the carotid artery was evaluated in three human cadaver samples based on the original axial acquisitio...

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Bibliographic Details
Published in:Cardiovascular and interventional radiology 2004-11, Vol.27 (6), p.651-654
Main Authors: Mohr, Andreas, Wenke, Ruediger, Roemer, Frank W, Lynch, John A, Gatzka, Christian, Priebe, Markus, Guermazi, Ali, Grigorian, Mikayel, Heller, Martin, Mueller-Huelsbeck, Stefan
Format: Article
Language:English
Subjects:
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ARTERIOSCLEROSIS
Arteriosclerosis - diagnostic imaging
Atherosclerosis
BIOMEDICAL RADIOGRAPHY
Cadaver
CAROTID ARTERIES
Carotid Arteries - diagnostic imaging
Carotid Artery Diseases - diagnostic imaging
COMPUTERIZED TOMOGRAPHY
EVALUATION
Humans
Image Processing, Computer-Assisted - methods
Imaging, Three-Dimensional - methods
Male
RADIOLOGY AND NUCLEAR MEDICINE
Tomography, X-Ray Computed - methods
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Summary:Micro-computed tomography (micro-CT) is a high-resolution, non-destructive tool for two- and three-dimensional imaging and quantification. The ability of this technique to assess atherosclerosis of the carotid artery was evaluated in three human cadaver samples based on the original axial acquisitions, multiplanar reconstructions and volume rendering techniques. Quantitative analysis included the calculation of: (1) the original lumen perimeter, original lumen area, plaque area, residual lumen area, calcified area and gross sectional area reduction of the vascular lumen from two-dimensional slices; (2) the total tissue volume, soft tissue volume and calcified tissue volume from the three-dimensional data set. This preliminary study demonstrates the potential of micro-CT as a supplementary method for the two- and three-dimensional ex vivo evaluation of carotid atherosclerosis.
ISSN:0174-1551
1432-086X
DOI:10.1007/s00270-003-0128-4