Use of the Trellis Peripheral Infusion System for enhancement of rt-PA thrombolysis in acute lower limb ischemia

The Trellis Peripheral Infusion System is an over-the-wire 0.035" guidewire compatible device, designed to isolate a region of the peripheral vasculature to allow for lytic drug infusion and dispersion. We used it successfully through a percutaneous approach in two cases of acute thrombosis of...

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Bibliographic Details
Published in:Cardiovascular and interventional radiology 2003-11, Vol.26 (6), p.572-575
Main Authors: TSETIS, Dimitrios K, KATSAMOURIS, Asterios N, ANDROULAKAKIS, Zacharias, CHAMALAKIS, Konstantinos, KOSTAS, Theodoros, CHLAPOUTAKIS, Konstantinos, GOURTSOYIANNIS, Nicholas C
Format: Article
Language:English
Subjects:
Acute Disease
Aged
ARTERIES
Biological and medical sciences
Cardiology. Vascular system
DISSOLUTION
DRUGS
Fibrinolytic Agents - administration & dosage
Fibrinolytic Agents - therapeutic use
Humans
INFUSION
Infusion Pumps
INJECTION
Investigative techniques, diagnostic techniques (general aspects)
ISCHEMIA
Ischemia - drug therapy
Ischemia - etiology
LIMBS
Lower Extremity - blood supply
Male
Medical sciences
Middle Aged
RADIOLOGY AND NUCLEAR MEDICINE
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Recombinant Proteins - administration & dosage
Recombinant Proteins - therapeutic use
Thrombolytic Therapy - instrumentation
THROMBOSIS
Thrombosis - complications
Tissue Plasminogen Activator - administration & dosage
Tissue Plasminogen Activator - therapeutic use
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Description
Summary:The Trellis Peripheral Infusion System is an over-the-wire 0.035" guidewire compatible device, designed to isolate a region of the peripheral vasculature to allow for lytic drug infusion and dispersion. We used it successfully through a percutaneous approach in two cases of acute thrombosis of a native lower limb artery. The total amount of rt-PA used was 12 and 9 mg, respectively and was delivered through bolus injections obviating the need for a supplementary continuous infusion of the agent. The time for dissolution of thrombus was 45 and 35 minutes, respectively. No complications were observed.
ISSN:0174-1551
1432-086X
DOI:10.1007/s00270-003-0033-x