State-of-the-art and problems of X-ray diffraction analysis of biomacromolecules

The state-of-the-art of X-ray diffraction studies of biomacromolecules is briefly characterized, and the challenge imposed by science is discussed. These studies are characterized by a wide scope and extensive use. This field of science is of great interest and is developed in many countries. The ma...

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Published in:Crystallography reports 2006-12, Vol.51 (6), p.988-993
Main Author: Andreeva, N. S.
Format: Article
Language:English
Subjects:
CHEMICAL INDUSTRY
DRUGS
ENZYMES
INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY
MEDICINE
PHYSICAL CHEMISTRY
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description The state-of-the-art of X-ray diffraction studies of biomacromolecules is briefly characterized, and the challenge imposed by science is discussed. These studies are characterized by a wide scope and extensive use. This field of science is of great interest and is developed in many countries. The main purpose is to solve practical problems in medicine consisting in the design of drugs against various diseases. X-ray diffraction analysis of enzymes brought the pharmaceutical industry to a new level, thus allowing the rational design of drugs against formerly untreatable diseases. Modern X-ray diffraction studies of biomacromolecules laid the basis for a new science called structural biology. This method allows one to solve fundamental problems of physical chemistry for a new state of matter existing in living systems. Here, science poses numerous problems in analysis of X-ray diffraction data on biological macromolecules. Many of theses problems are in their infancy.
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subjects CHEMICAL INDUSTRY
DRUGS
ENZYMES
INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY
MEDICINE
PHYSICAL CHEMISTRY
title State-of-the-art and problems of X-ray diffraction analysis of biomacromolecules
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