Drosophila arginine methyltransferase 1 (DART1) is an ecdysone receptor co-repressor

Histone arginine methylation is an epigenetic marker that regulates gene expression by defining the chromatin state. Arginine methyltransferases, therefore, serve as transcriptional co-regulators. However, unlike other transcriptional co-regulators, the physiological roles of arginine methyltransfer...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2008-07, Vol.371 (4), p.889-893
Main Authors: Kimura, Shuhei, Sawatsubashi, Shun, Ito, Saya, Kouzmenko, Alexander, Suzuki, Eriko, Zhao, Yue, Yamagata, Kaoru, Tanabe, Masahiko, Ueda, Takashi, Fujiyama, Sari, Murata, Takuya, Matsukawa, Hiroyuki, Takeyama, Ken-ichi, Yaegashi, Nobuo, Kato, Shigeaki
Format: Article
Language:English
Subjects:
60 APPLIED LIFE SCIENCES
Animals
ARGININE
Arginine methyltransferase
CHROMATIN
Co-repressor
DART1
DROSOPHILA
Drosophila melanogaster
Drosophila melanogaster - enzymology
Drosophila melanogaster - genetics
Drosophila melanogaster - growth & development
Drosophila Proteins - genetics
Drosophila Proteins - metabolism
Ecdysone receptor
GENES
Genes, Lethal
Histone modification
Histones - metabolism
HORMONES
Immunoprecipitation
LIGANDS
METAMORPHOSIS
METHYLATION
Methyltransferases - genetics
Methyltransferases - metabolism
Mutation
RECEPTORS
Receptors, Steroid - metabolism
Repressor Proteins - genetics
Repressor Proteins - metabolism
TRANSCRIPTION
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Summary:Histone arginine methylation is an epigenetic marker that regulates gene expression by defining the chromatin state. Arginine methyltransferases, therefore, serve as transcriptional co-regulators. However, unlike other transcriptional co-regulators, the physiological roles of arginine methyltransferases are poorly understood. Drosophila arginine methyltransferase 1 (DART1), the mammalian PRMT1 homologue, methylates the arginine residue of histone H4 (H4R3me2). Disruption of DART1 in Drosophila by imprecise P-element excision resulted in low viability during metamorphosis in the pupal stages. In the pupal stage, an ecdysone hormone signal is critical for developmental progression. DART1 interacted with the nuclear ecdysone receptor (EcR) in a ligand-dependent manner, and co-repressed EcR in intact flies. These findings suggest that DART1, a histone arginine methyltransferase, is a co-repressor of EcR that is indispensable for normal pupal development in the intact fly.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2008.05.003