Polycrystalline silicon: A biocompatibility assay

Polycrystalline silicon (poly-Si) layers were functionalized through the growth of biomimetic hydroxyapatite (HA) on their surface. HA is the mineral component of bones and teeth and thus possesses excellent bioactivity and biocompatibility. MG-63 osteoblast-like cells were cultured on both HA-coate...

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Bibliographic Details
Published in:AIP conference proceedings 2010, Vol.1203 (1), p.909-913
Main Authors: Pecheva, E., Laquerroere, P., Bouthors, S., Fingarova, D., Pramatarova, L., Hikov, T., Dimova-Malinovska, D., Montgomery, P.C.
Format: Article
Language:English
Subjects:
AFFINITY
ANIMAL CELLS
APATITES
BODY
CHEMICAL COMPOSITION
CONNECTIVE TISSUE CELLS
CRYSTAL GROWTH
CRYSTALS
DIGESTIVE SYSTEM
ELEMENTS
GRAFT-HOST REACTION
LASER SPECTROSCOPY
LAYERS
MATERIALS SCIENCE
MINERALS
MORPHOLOGY
ORAL CAVITY
ORGANS
PHOSPHATE MINERALS
POLYCRYSTALS
RAMAN SPECTROSCOPY
ROUGHNESS
SEMIMETALS
SILICON
SKELETON
SOMATIC CELLS
SPECTROSCOPY
SPUTTERING
SURFACE PROPERTIES
SURFACES
TEETH
TOXICITY
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Summary:Polycrystalline silicon (poly-Si) layers were functionalized through the growth of biomimetic hydroxyapatite (HA) on their surface. HA is the mineral component of bones and teeth and thus possesses excellent bioactivity and biocompatibility. MG-63 osteoblast-like cells were cultured on both HA-coated and un-coated poly-Si surfaces for 1, 3, 5 and 7 days and toxicity, proliferation and cell morphology were investigated. The results revealed that the poly-Si layers were bioactive and compatible with the osteoblast-like cells. Nevertheless, the HA coating improved the cell interactions with the poly-Si surfaces based on the cell affinity to the specific chemical composition of the bone-like HA and/or to the higher HA roughness.
ISSN:0094-243X
1551-7616
DOI:10.1063/1.3322581