Treatment Planning for Accelerator-Based Boron Neutron Capture Therapy

Glioblastoma multiforme and metastatic melanoma are frequent brain tumors in adults and presently still incurable diseases. Boron Neutron Capture Therapy (BNCT) is a promising alternative for this kind of pathologies. Accelerators have been proposed for BNCT as a way to circumvent the problem of sit...

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Bibliographic Details
Main Authors: Herrera, Maria S., Gonzalez, Sara J., Minsky, Daniel M., Kreiner, Andres J., Escuela de Ciencia y Tecnologia, UNSAM, Buenos Aires
Format: Conference Proceeding
Language:English
Subjects:
ACCELERATORS
ADULTS
AGE GROUPS
BARYONS
BODY
BORON
BRAIN
CALCULATION METHODS
CARCINOMAS
CENTRAL NERVOUS SYSTEM
DISEASES
DOSES
DOSIMETRY
ELEMENTARY PARTICLES
ELEMENTS
EPITHELIOMAS
EPITHERMAL NEUTRONS
FERMIONS
GLIOMAS
HADRONS
MEDICINE
MELANOMAS
METASTASES
MONTE CARLO METHOD
NEOPLASMS
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NEUTRON CAPTURE THERAPY
NEUTRON SOURCES
NEUTRON THERAPY
NEUTRONS
NUCLEAR MEDICINE
NUCLEAR REACTIONS
NUCLEONS
ORGANS
PARTICLE SOURCES
PATHOLOGY
PATIENTS
PLANNING
RADIATION DOSE DISTRIBUTIONS
RADIATION DOSES
RADIATION SOURCES
RADIOLOGY
RADIOLOGY AND NUCLEAR MEDICINE
RADIOTHERAPY
SEMIMETALS
SIMULATION
SKIN
THERAPY
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Summary:Glioblastoma multiforme and metastatic melanoma are frequent brain tumors in adults and presently still incurable diseases. Boron Neutron Capture Therapy (BNCT) is a promising alternative for this kind of pathologies. Accelerators have been proposed for BNCT as a way to circumvent the problem of siting reactors in hospitals and for their relative simplicity and lower cost among other advantages. Considerable effort is going into the development of accelerator-based BNCT neutron sources in Argentina. Epithermal neutron beams will be produced through appropriate proton-induced nuclear reactions and optimized beam shaping assemblies. Using these sources, computational dose distributions were evaluated in a real patient with diagnosed glioblastoma treated with BNCT. The simulated irradiation was delivered in order to optimize dose to the tumors within the normal tissue constraints. Using Monte Carlo radiation transport calculations, dose distributions were generated for brain, skin and tumor. Also, the dosimetry was studied by computing cumulative dose-volume histograms for volumes of interest. The results suggest acceptable skin average dose and a significant dose delivered to tumor with low average whole brain dose for irradiation times less than 60 minutes, indicating a good performance of an accelerator-based BNCT treatment.
ISSN:0094-243X
1551-7616
DOI:10.1063/1.3480233