Ophthalmic Artery Embolization as Pretreatment of Orbital Exenteration for Conjunctival Squamous Cell Carcinoma

• Published in: Cardiovascular and interventional radiology 2009-05, Vol.32 (3), p.554-557
• Main Authors: Matsuo, Toshihiko, Ohara, Nobuya, Namba, Yuzaburo, Koshima, Isao, Ida, Kentaro, Kanazawa, Susumu
• Format: Article
• Language: English
• Subjects: Aged; ANIMAL CELLS; ARTERIES; BLOOD VESSELS; BODY; Carcinoma, Squamous Cell - surgery; Carcinoma, Squamous Cell - therapy; CARCINOMAS; Cardiology; CARDIOVASCULAR SYSTEM; Case Report; CONJUNCTIVA; Conjunctiva - blood supply; Conjunctiva - pathology; Conjunctival Neoplasms - surgery; Conjunctival Neoplasms - therapy; DEFORMATION; DIAGNOSTIC TECHNIQUES; DISEASES; Embolization, Therapeutic - methods; EYES; FACE; HEAD; HEMORRHAGE; Humans; Imaging; Magnetic Resonance Imaging; Male; Medicine; Medicine & Public Health; MEMBRANES; MUCOUS MEMBRANES; NEOPLASMS; NMR IMAGING; Nuclear Medicine; Ophthalmic Artery; Orbit Evisceration; ORGANS; PATHOLOGICAL CHANGES; Radiology; RADIOLOGY AND NUCLEAR MEDICINE; SENSE ORGANS; Surgical Flaps; SWELLING; SYMPTOMS; TUMOR CELLS; Ultrasound
• ISSN: 0174-1551; 1432-086X
• DOI: 10.1007/s00270-008-9413-6

The aim of this study is to describe the effect of transarterial embolization from the ophthalmic artery as a pretreatment for orbital exenteration. A 75-year-old Chinese man with a 7-year history of gradual increase of the left eye swelling showed a massive conjunctival tumor growing outwardly from the interpalpebral fissure and had no light perception in the left eye. Magnetic resonance imaging showed orbital invasion of the tumor around the left eyeglobe. The initial surgery for the planned orbital exenteration was discontinued after skin incision around the orbital margin due to massive hemorrhage. The patient underwent transarterial embolization with gelatin sponge (Spongel) of the feeding arteries from the left ophthalmic artery and, the next day, had orbital exenteration with well-controllable bleeding and reconstruction with free vascularized anterolateral thigh cutaneous flap transfer. Pathologically, well-differentiated squamous cell carcinoma proliferated in exophytic, papillary, and nested fashions, arising from the bulbar conjunctiva. Tumor cells were also found in the conjunctival stroma around the vessels. The sclera at the equator had a perforated site with tumor cell invasion, but no intraocular invasion was found. Hematoxylin-positive gelatin sponges were found inside the orbital vessels and large choroidal vessels. In conclusion, transarterial embolization of feeding arteries arising from the ophthalmic artery is a useful pretreatment to control bleeding at orbital exenteration for malignancy.