Nanoparticles as contrast-enhancing agents in optical coherence tomography imaging of the structural components of skin: Quantitative evaluation

This work examines the effect of gold nanoshells and titania nanoparticles on the imaging contrast of structural components of skin in optical coherence tomography (OCT). Experimental data are compared to Monte Carlo (MC) simulation results. In experiments with pig skin in vivo, the epidermis - derm...

Full description

Saved in:
Bibliographic Details
Published in:Quantum electronics (Woodbury, N.Y.) N.Y.), 2010-08, Vol.40 (6), p.525-530
Main Authors: Kirillin, M Yu, Agrba, P D, Sirotkina, M A, Shiryamova, M V, Zagainova, E V, Kamenskii, V A
Format: Article
Language:English
Subjects:
ANIMAL TISSUES
ANIMALS
BODY
CALCULATION METHODS
CHALCOGENIDES
DATA
DIAGNOSTIC TECHNIQUES
DOMESTIC ANIMALS
ELEMENTS
EPIDERMIS
EPITHELIUM
EXPERIMENTAL DATA
GLANDS
GOLD
IN VIVO
INFORMATION
MAMMALS
METALS
MONTE CARLO METHOD
NANOSCIENCE AND NANOTECHNOLOGY
NANOSTRUCTURES
NUMERICAL DATA
ORGANS
OXIDES
OXYGEN COMPOUNDS
SIMULATION
SKIN
SURFACES
SWINE
TITANIUM COMPOUNDS
TITANIUM OXIDES
TOMOGRAPHY
TRANSITION ELEMENT COMPOUNDS
TRANSITION ELEMENTS
VERTEBRATES
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This work examines the effect of gold nanoshells and titania nanoparticles on the imaging contrast of structural components of skin in optical coherence tomography (OCT). Experimental data are compared to Monte Carlo (MC) simulation results. In experiments with pig skin in vivo, the epidermis - dermis contrast is improved from 0.78 {+-} 0.03 to 0.92 {+-} 0.04 by gold nanoshells applied to the skin surface and from 0.78 {+-} 0.03 to 0.86 {+-} 0.04 by titania nanoparticles. The contrast of glands is enhanced by titania from 0.68 {+-} 0.12 to 0.84 {+-} 0.07. The highest contrast is reached 120 - 150 min after applying gold nanoshells and 160 - 200 min after applying titania. According to the MC simulation results, the contrast of inclusions increases from zero to 0.85 and 0.65, respectively. (optical tomography)
ISSN:1063-7818
1468-4799
DOI:10.1070/QE2010v040n06ABEH014294