Magnetite Nanoparticles Coated with Rifampicin and Chlortetracycline for Drug Delivery Applications

Four types of biocompatible magnetic fluids based on superparamagnetic nanoparticles with Fe{sub 3}O{sub 4} cores were functionalized with antibiotics (rifampicin or chlortetracycline) as potential candidates for in vivo biomedical applications, such as magnetically controlled drug delivery. The syn...

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Bibliographic Details
Main Authors: Nadejde, Claudia, Ciurlica, Ecaterina Foca-nici, Creanga, Dorina, Carlescu, Aurelian, Badescu, Vasile
Format: Conference Proceeding
Language:English
Subjects:
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
AQUEOUS SOLUTIONS
CHALCOGENIDES
COHERENT SCATTERING
COPRECIPITATION
DELIVERY
DIFFRACTION
DISPERSIONS
DRUGS
ELECTRON MICROSCOPY
FERRIMAGNETIC MATERIALS
FERRITES
FLUIDS
HOMOGENEOUS MIXTURES
IN VIVO
IRON COMPOUNDS
IRON ORES
IRON OXIDES
MAGNETIC MATERIALS
MAGNETISM
MAGNETITE
MAGNETOMETERS
MATERIALS
MEASURING INSTRUMENTS
MICROSCOPY
MINERALS
MIXTURES
NANOSCIENCE AND NANOTECHNOLOGY
NANOSTRUCTURES
ORES
ORGANIC COMPOUNDS
OXIDE MINERALS
OXIDES
OXYGEN COMPOUNDS
PRECIPITATION
SCANNING ELECTRON MICROSCOPY
SCATTERING
SEPARATION PROCESSES
SOLUTIONS
STABILITY
SUPERPARAMAGNETISM
SYNTHESIS
TETRACYCLINES
TRANSITION ELEMENT COMPOUNDS
TRANSMISSION ELECTRON MICROSCOPY
VIBRATING SAMPLE MAGNETOMETERS
X-RAY DIFFRACTION
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Description
Summary:Four types of biocompatible magnetic fluids based on superparamagnetic nanoparticles with Fe{sub 3}O{sub 4} cores were functionalized with antibiotics (rifampicin or chlortetracycline) as potential candidates for in vivo biomedical applications, such as magnetically controlled drug delivery. The synthesis consisted in coprecipitation of iron oxide in basic, as well as in acid medium, followed by the dispersion of the resulted magnetite nanoparticles in aqueous solution containing the antibiotic. The chosen method to prepare the magnetite-core/drug-shell systems avoided intermediate organic coating of the magnetic nanoparticles. Comparative analysis of the rheological features of the aqueous magnetic fluid samples was performed. The structural features of the coated magnetic particles were investigated by X-Ray Diffraction (XRD), Transmission Electron Microscopy (TEM) and Vibrating Sample Magnetometry (VSM). Good crystallinity and adequate stability in time were evidenced. Drug delivery curves were spectrophotometrically provided.
ISSN:0094-243X
1551-7616
DOI:10.1063/1.3530043